The 49ers will be starting backups at nearly every non-offensive line position on offense against the Giants on Sunday. Despite George Kittle getting in three limited practices this week, the 49ers will hold their All-Pro tight end out.
Same goes for Jimmy Garoppolo, though San Francisco’s staring quarterback did not practice this week. The 49ers will play a game without their starting quarterback, their top two running backs from Super Bowl LIV, their No. 1 wide receiver and their recently extended tight end.
Kittle is on his way back from a knee sprain, and the three limited practices point to the 49ers having him ready to go against the Eagles in Week 4. But the 27-year-old star pass catcher will miss two games for a second straight season.
Nick Mullens will start for Garoppolo, who ended up receiving better-than-expected news about his high ankle sprain, and a currently healthy Jordan Reed will line up as the 49ers’ first-string tight end at the same MetLife Stadium venue that further depleted the team’s depth chart.
The list of would-be 49ers starters/key contributors who will not be in uniform against the Giants: Garoppolo, Kittle, Raheem Mostert, Tevin Coleman, Deebo Samuel, Weston Richburg, Nick Bosa, Dee Ford, Solomon Thomas, Dre Greenlaw and Richard Sherman.
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