Every week, there seems to be something injury-related coming out of the Bay Area. Whether it’s somebody preparing to miss a lot of time, a “will he” or “won’t he” gametime decision, or questions on timetables for return, the 49ers have provided headlines all season. The latest such headline pertains to the middle option as a questionable Brock Purdy will watch Mac Jones start for the sixth week in a row, per Tom Pelissero of NFL Network. 
It’s become a weekly post with Purdy, who has been on the team’s injury report every week since he was hurt in the season opener. The 25-year-old has been getting closer and closer to coming back, and head coach Kyle Shanahan communicated that he could still be active as a backup to Jones. Third-string passer Adrian Martinez was signed from the practice squad to the active roster back in October as Purdy was nearing a return back then, so with three quarterbacks on the 53-man, Purdy could either be a primary backup or an emergency third option.
The quarterback role we do know, though, will be Jones, who will start under center for the eighth time this year. After winning his first three starts as an injury replacement, Jones has cooled off, alternating losses and wins since then. Despite a largely injured supporting cast around him, Jones is averaging a career-high 261.7 passing yards per game while also sporting the best touchdown:interception ratio (10:5) of his career. He’ll be looking to buck the trend of alternating finishes after beating the Giants last week.
One player we know won’t be out there is wide receiver Ricky Pearsall. The second-year pass-catcher has been missing since Week 4 and is about to miss his sixth game in a row. Asked about what’s holding Pearsall from being able to play, Shanahan told the media that “he hasn’t been able to hit his normal speeds that would allow him to come back,” per Cam Inman of the Bay Area News Group. Reporters noted the young wideout had been sighted doing sprints at practices and shooting jump shots in the locker room, but Shanahan was adamant that the team is waiting for Pearsall to be able to hit his old marks.
Pearsall isn’t the only receiver unavailable this week. Veteran wideout Brandon Aiyuk remains on the reserve/PUP list ten weeks into the season. November was offered up last month as a potential return window for the 27-year-old receiver. It’s now been over a year since Aiyuk has appeared in a game, and each week, expectations for Aiyuk’s 21-day practice window to be opened go unrealized. Shanahan continues to seem vaguely optimistic, with Vic Tafur of The Athletic quoting him as “pretty confident” that Aiyuk will be back sometime this season.
Given the extended absences of players like Purdy and Pearsall, among some others, there have been questions on why players missing so much time weren’t put on injured reserve. According to The Athletic’s Matt Barrows, the primary reason is simply that they didn’t expect each player to be out for so long. Additionally, while the NFL has implemented the current system wherein teams can bring players back from IR, each team is only given eight such activations.
Lucky teams can put players with minor injuries on IR and activate them four weeks later just to manipulate roster numbers. With so many injuries week in and week out, the 49ers likely would’ve loved to place guys on IR so they could add healthy reinforcements to the roster. Knowing how many impact players they had already placed on IR, though, San Francisco needed to be weary of how it would be able to utilize its limited activations.
One player that did land on IR recently was edge rusher Yetur Gross-Matos. Gross-Matos had been out since Week 5 and was expected to make a return soon. Unfortunately, the 27-year-old defender strained his hamstring again near the end of last week, per ESPN’s Nick Wagoner. While it will take Gross-Matos some time to work his way back from the injury, Shanahan doesn’t believe he will be sidelined for the remainder of the season.
