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49ers To Activate George Kittle, Rule Out Brock Purdy

October 17th, 2025 at 5:01pm CST by Nikhil Mehta

The 49ers ruled out quarterback Brock Purdy for Week 7, per The Athletic’s Vic Tafur, meaning that Mac Jones will make his fifth start of the season.

Purdy was still limited in practice this week due to a re-aggravation of his toe injury. Jones, meanwhile, progressed to full participation despite dealing with knee and oblique injuries. He has led the 49ers to a 3-1 record in his four starts with a league-high 313 passing yards per game.

Head coach Kyle Shanahan also said (via ESPN’s Nick Wagoner) that tight end George Kittle would be activated from injured reserve for Sunday’s game, ending his four-game absence due to a Week 1 hamstring injury. Kittle is not expected to be on any kind of snap count, according to Tafur.

San Francisco created the space for Kittle’s activation on Friday by placing wide receiver Marquez Valdes-Scantling on injured reserve, per Wagoner. The eight-year veteran will now be on the shelf for at least four games with a calf injury and becomes the latest 49ers wideout to miss time. Ricky Pearsall has been out for the last two games with a knee issue that will sideline him for Sunday’s contest as well. Jacob Cowing is on IR, though Shanahan said (via Wagoner) that he is “getting close” to returning to practice. Jauan Jennings has missed two games and played through four others with a litany of injuries. That’s not even mentioning Brandon Aiyuk, who will not be back until November at the earliest.

Kittle’s return will obviously go a long way in relieving the pressure on the 49ers’ injured receiving corps. Backup tight end Jake Tonges has performed well in his absence, giving Shanahan the options of using more two-tight end formations until the rest of his offense gets healthier.

Shanahan also said that defensive tackle Kevin Givens will “most likely” be activated from IR as well, which would add depth to a defensive line that has also dealt with a number of injuries this year. The 49ers can easily create a roster spot for Givens by placing linebacker Fred Warner on injured reserve after an ankle injury that is expected to end his season.

49ers Less Likely To Pursue Trades?

October 17th, 2025 at 11:09am CST by Adam La Rose

Not long after Nick Bosa suffered a torn ACL, John Lynch confirmed the 49ers were in the market for a trade aimed at adding a pass rusher. Trey Hendrickson in particular has emerged as a name to watch in that regard.

However, Week 6 saw linebacker Fred Warner suffer a fractured and dislocated ankle. The All-Pro is expected to miss the remainder of the campaign as a result. With San Francisco’s defense now missing two major contributors the rest of the way, the team’s general manager appears to have changed his stance on the subject of pursuing a short-term addition on the trade market.

“It’s time to go play. And we’ve got plenty in this team to go compete and go win football games,” Lynch said during his latest appearance on KNBR radio (via Eric Branch of the San Francisco Chronicle). “And you do your due diligence — you put the work in. Are there variables that change from week to week? Absolutely, there are. And we’ll just leave it at that.”

Indeed, the 49ers’ calculus has no doubt shifted with Bosa and now Warner out of the picture. The team sits at 4-2, but sacrificing draft capital for a rental could be more difficult to justify given the state of the defense on the injury front. In any event, the play of San Francisco’s internal options will be key in replacing Bosa and Warner down the stretch.

Hendrickson is one of several edge rushers who have emerged as trade candidates ahead of the November 4 deadline. Fewer linebackers have been mentioned in the same capacity, though. As things stand, Tatum Bethune is in position to assume a starting role in Warner’s place. The 2024 seventh-rounder has been a regular on special teams early in his career, but he has logged just 99 snaps on defense in the regular season. How Bethune fares with an increased workload will surely influence Lynch’s aggressiveness on the trade front.

With over $21MM in cap space, the 49ers can certainly afford a short-term acquisition. Based on Lynch’s latest comments, however, the team may prefer to avoid any notable outside additions and instead proceed with its in-house replacement options.

49ers, Colts, Eagles, Cowboys Among Potential Suitors For Trey Hendrickson

October 16th, 2025 at 10:59pm CST by Nikhil Mehta

All-Pro edge rusher Trey Hendrickson has emerged as a popular name in trade talks following an offseason contract saga with the Bengals and their subsequent 2-4 start to the season.

The 49ers are among the teams interested in trading for Hendrickson, though Cincinnati is reportedly not interested in moving him. Other expected suitors include the Colts, Eagles, and Cowboys, per Sportskeeda’s Tony Pauline. Hendrickson is owed $9.8MM for the rest of the season if traded after Week 8 ($8.9MM if after Week 9, per OverTheCap), and the Bengals will likely want an acquiring team to pick up all of his remaining salary.

We noted when the Colts restructured Kenny Moore‘s contract earlier this month that general manager Chris Ballard could be clearing space for a big swing ahead of the trade deadline to take advantage of a surprising 5-1 start. Going after Hendrickson, one of the league’s premier edge rushers, would certainly fall into that category. Indianapolis does not necessarily need the pass rush help – their 16 sacks are tied for seventh-most in the NFL – but no individual player has more than 3.0 sacks. Instead, they have 11 defenders who have contributed to a sack this year; adding Hendrickson to that group would give them an elite individual sack-getter on top of a well-schemed pass rush.

Eagles general manager Howie Roseman has a reputation of being a big-name hunter on the trade market, but most of his higher-profile deals have come during the offseason. However, Philadelphia has a bottom-10 pass rush with only nine sacks as a team and no player with more than two. Nolan Smith and Ogbo Okoronkwo are already on injured reserve, and Za’Darius Smith just retired, so the Eagles defense could definitely use reinforcements on the edge. Roseman’s aggressive cap management has given the team enough room to absorb’s Hendrickson’s contract, though it would tighten their budget for the rest of the season.

The Cowboys pass rush has predictably struggled following the departures of Micah Parsons and DeMarcus Lawrence, leading to one of the worst defensive units in the NFL. Jerry Jones recently hinted that he could be active ahead of the trade deadline, and he acknowledge that every asset would be on the table, including the picks acquired from Green Bay in the Parsons trade. The Cowboys could certainly use a player of Hendrickson’s caliber, as they currently have the ninth-fewest sacks in the NFL (11).

We heard recently that the 49ers see Hendrickson as “an ideal fit for their defense.” The team lost star pass rusher Nick Bosa to a season-ending ACL tear in Week 3, and 49ers general manager John Lynch has made it known that he’s looking for help on the edge. That front office hasn’t been afraid to take in-season swings, and it wouldn’t be surprising if the team acquired a player of Hendrickson’s talent as they look to maximize their current core.

As mentioned, the Bengals have resisted any trade inquires for their star pass rusher. However, if the team doesn’t improve as the trade deadline inches closer, there’s a chance the team starts fielding offers.

Ben Levine contributed to this post.

Mac Jones Likely To Start Week 7; George Kittle Plans To Return

October 16th, 2025 at 9:51pm CST by Connor Byrne

It appears 49ers backup quarterback Mac Jones will make his third straight start in place of Brock Purdy in Week 7. While Jones has been dealing with knee and oblique issues, he was able to practice in full on Thursday. With Purdy limited because of a nagging toe injury, head coach Kyle Shanahan said that Jones will “most likely” start against the Falcons on Sunday (via Eric Branch of the San Francisco Chronicle).

After playing 31 of a possible 34 regular-season games from 2023-24, Purdy has already sat out four times this year. He started a season-opening win over the Seahawks and a Week 4 loss to the Jaguars. The offseason decision to sign Jones, a former Patriot and Jaguar, has helped the injury-plagued 49ers stay afloat during a 4-2 start.

While Jones struggled in a loss to the Buccaneers last Sunday, the 49ers have gone 3-1 with him at the helm. The 27-year-old has connected on 67.3% of passes for 1,252 yards, six touchdowns, and three interceptions.

Jones’ success has come without six-time Pro Bowl tight end George Kittle, who’s among the Niners’ many walking wounded, but that could change Sunday. Kittle suffered a right hamstring injury in Week 1 – a “full tear,” he revealed – leading the 49ers to place him on IR. After missing five consecutive games, Kittle returned to practice on Wednesday. He took part in his second limited session in a row Thursday and expressed confidence about his chances of facing the Falcons.

“I fully plan on playing on Sunday,” Kittle said, though he acknowledged that Shanahan will make the call (via Nick Wagoner of ESPN.com).

While Jones may count Kittle among his weapons for the first time on Sunday, he could go without wide receiver Ricky Pearsall again. After missing San Francisco’s past two games with a knee injury, the second-year man has not returned to practiced this week.

49ers LB Fred Warner Undergoes Surgery

October 16th, 2025 at 11:14am CST by Adam La Rose

OCTOBER 16: Shanahan noted (via Matt Barrows of The Athletic) Warner’s surgery was a success. A firm recovery timeline is still not in place at this point, with Lynch stating during his latest KNBR appearance (h/t Barrows) he will soon speak with team doctors on that subject. Surgeons Barrows interviewed indicated a return during the playoffs could be possible, but the team’s stance on Warner’s injury being season-ending has not changed.

OCTOBER 14: The 49ers’ defense was dealt another crippling blow on Sunday when Fred Warner suffered a fractured and dislocated ankle. His recovery process will begin soon.

Warner is scheduled to undergo surgery tomorrow, Matt Maiocco of NBC Sports Bay area notes. When speaking about the injury, head coach Kyle Shanahan added he expects the four-time Pro Bowler to return to on-field activities at some point during the offseason. While a more definitive timeline will depend on the success of the procedure, the 49ers will move forward without one of their most important contributors for the rest of the season.

Over the course of his career (all of which has taken place with San Francisco), Warner has served as a full-time starter and a consistent high-end performer. The four-time All-Pro recorded between 118 and 137 tackles in each of his first seven seasons with the 49ers, but this injury will cause an absence beyond one game for the first time in Warner’s decorated tenure. With edge rusher Nick Bosa already sidelined, San Francisco’s defense faces a major challenge in terms of keeping the team in playoff contention.

General manager John Lynch has made it clear a trade is being worked on to acquire a pass rusher capable of replacing Bosa’s presence to an extent. It will be interesting to see if the 49ers – who lost Dre Greenlaw in free agency – will add linebacker to their list of positions targeted on the trade front. As ESPN’s Nick Wagoner writes, though, the loss of Warner hinders San Francisco’s chances of competing for a Super Bowl in 2025. Parting ways with future draft capital for a rental addition could therefore prove to be a misstep.

In any event, the 49ers are currently in position to lean on internal options as they look to replace Warner. That could result in Tatum Bethune taking on a starting defensive role moving forward. The 2024 seventh-rounder has operated as a regular on special teams over the course of his first two seasons in the league. Bethune only logged 51 snaps on defense as a rookie, however, and his total in that regard sits at 48 after he filled in for Warner in Week 6. The 49ers’ plan regarding any LB moves will be based in part on how Bethune fares in his expanded role.

Sunday’s loss leaves San Francisco as one of three teams in the NFC West with a 4-2 record. Plenty of time remains for the team’s season to swing one way or the other as a result. Ahead of the 2026 campaign, though, Warner’s progress in rehabbing after surgery will be a key story to follow.

NFL Practice Squad Updates: 10/15/25

October 15th, 2025 at 7:13pm CST by Ely Allen

Here are Wednesday’s practice squad transactions:

Arizona Cardinals

Buffalo Bills

Cleveland Browns

Jacksonville Jaguars

Kansas City Chiefs

Los Angeles Chargers

Philadelphia Eagles

San Francisco 49ers

  • Signed: T Isaac Alarcón

Seattle Seahawks

Both Jacksonville and San Francisco had their practice squads filled up with 16 players apiece, but Zierer and Alarcón were both able to be added as players in the league’s International Player Pathway Program. Zierer is a German-born lineman, and Alarcón was born in Mexico.

49ers Open George Kittle’s Practice Window

October 15th, 2025 at 3:09pm CST by Connor Byrne

Star tight end George Kittle has been on IR since Sept. 9, but he’s finally nearing a return. The 49ers opened Kittle’s practice window on Wednesday, according to Clayton Holloway of NFL Network. They’ll have 21 days to activate him.

Kittle, who suffered a hamstring injury in a Week 1 win over the Seahawks, will practice on a limited basis on Wednesday. Head coach Kyle Shanahan said that quarterbacks Brock Purdy and Mac Jones will join Kittle as limited participants (via Matt Barrows of The Athletic).

Purdy, out back-to-back games with a toe injury, is viewed as more limited than Jones. While Jones is battling knee and oblique issues, he could make his third straight start Sunday against the Falcons.

Kittle has already missed five games this season, which is the second-highest total of his nine-year career. The six-time Pro Bowler entered 2025 off four consecutive seasons of at least 14 games played. He continued to thrive during a 15-game slate in 2024, catching 78 passes for 1,106 yards and eight touchdowns.

The 49ers were likely expecting more of the same from Kittle this season. Instead, he has been among many high-profile injury casualties for the club. San Francisco’s offense has gotten one appearance from Kittle, two from Purdy, and none from receiver Brandon Aiyuk. On the other side of the ball, the team has seen heart-and-soul defenders Fred Warner and Nick Bosa go down with season-ending injuries in recent weeks. Despite that, the 49ers have gotten off to a 4-2 start.

Without Kittle, the 49ers have turned to the little-known Jake Tonges as their primary tight end. To Tonges’ credit, he has done well filling in for Kittle. He entered the season with no catches over four games (all with Chicago in 2022), but Tonges has racked up 25 receptions, 34 targets, 224 yards, and three scores in six contests this year. He’ll serve as a solid No. 2 option at tight end when Kittle is back in the lineup, perhaps as early as this week.

The 49ers could also get Aiyuk back soon, which will further bolster their offense down the stretch as they vie for a playoff berth. Facing a fellow NFC postseason contender this week in the 3-2 Falcons, the 49ers may again have to overcome a Purdy absence. After signing a five-year, $265MM contract extension in the offseason, Purdy has been sidelined for most of 2025. Jones has held his own as a fill-in, but thanks in part to his own injury troubles, he struggled in a loss to the Buccaneers in Week 6.

49ers Expected To Inquire About Bengals’ Trey Hendrickson

October 15th, 2025 at 11:10am CST by Connor Byrne

OCTOBER 15: The 49ers see Hendrickson as “an ideal fit for their defense,” but the Bengals have no intention of moving their All-Pro pass rusher, according to ESPN’s Jeremy Fowler and Dan Graziano. Cincinnati is holding out hope that newly-acquired quarterback Joe Flacco can keep them in contention unless and until Joe Burrow makes a late-season return. More losses before the trade deadline could always change those plans, but the Bengals do have a relatively easy three-game stretch coming up.

OCTOBER 11: Having lost star pass rusher Nick Bosa to a season-ending ACL tear in Week 3, 49ers general manager John Lynch has made it known that he’s looking for help at defensive end. Lynch’s interest in finding a Bosa replacement could lead to a trade before the Nov. 4 deadline. To that end, Dianna Russini of The Athletic expects the 49ers to call the Bengals about Trey Hendrickson.

The 2-3 Bengals aren’t declaring themselves as sellers yet. On the contrary, they acquired quarterback Joe Flacco from the Browns earlier this week in an effort to keep their season alive. Flacco will start Sunday against the Packers in place of the demoted Jake Browning, who struggled mightily replacing the injured Joe Burrow.

It’s a long shot that the 40-year-old Flacco will rescue a deeply flawed Cincinnati team that’s on the outside of the playoff picture. If he doesn’t, it could behoove the Bengals to sell Hendrickson to the highest bidder in the next few weeks.

After his second straight 17.5-sack showing in 2024, Hendrickson and the Bengals continued a long standoff regarding his contract during the offseason. They finally agreed to a revised deal in late August, thus preventing Hendrickson from holding out into the regular season.

While Hendrickson’s amended contract didn’t add any years, it did increase his 2025 salary from $15.8MM to $30MM. The soon-to-be 31-year-old is due to reach free agency in the offseason, when he’ll likely price himself out of Cincinnati. That’s assuming he even finishes the season as a Bengal. If he does, the Bengals could place the franchise tag on Hendrickson, but it would cost upward of $35MM to keep him under wraps. That may be tough to swing for a team that already has exorbitant commitments in Burrow, Ja’Marr Chase, and Tee Higgins for 2026. That trio of offensive core players will combine to count approximately $100MM against the salary cap next season.

Burrow’s toe injury has been the Bengals’ main problem this season, but it isn’t the only culprit for their poor start. Despite Hendrickson’s presence, their defense ranks 30th in the NFL in points and yardage surrendered. That’s another reason a 2025 turnaround looks unlikely for the club. Hendrickson hasn’t done anything to hurt his trade value, though, having notched four sacks and eight quarterback hits over the first five games of the season. He’s Pro Football Focus’ (subscription required) 11th-ranked EDGE player this year.

While the Bengals may eventually sell, the 49ers are lining up as buyers after a 4-1 start. They’ve weathered a series of injuries to key players – Bosa, quarterback Brock Purdy, and tight end George Kittle, among others – to reemerge as NFC contenders after a down 2024. They’ve succeeded despite an anemic pass rush that ranks 30th in the league in sacks. Bosa and Bryce Huff have combined for five of the 49ers’ six sacks. Cornerback Upton Stout has the other, meaning the majority of the 49ers’ front seven has been shut out.

Although it may not turn out to be Hendrickson, it seems like a given that the 49ers will bring in a complement (or complements) to Huff by early November. With around $24MM in cap space, the 49ers are as well-positioned as anyone to make an expensive splash. That could mean reeling in Hendrickson if the Bengals ultimately wave the white flag on their season.

NFL Practice Squad Updates: 10/14/25

October 14th, 2025 at 7:55pm CST by Ben Levine

Today’s practice squad moves:

Baltimore Ravens

Buffalo Bills

Cleveland Browns

Denver Broncos

  • Signed: G Karsen Barnhart, LB Garrett Nelson

Green Bay Packers

  • Released: K Mark McNamee

Indianapolis Colts

  • Signed: OT Bayron Matos, QB Brett Rypien
  • Released: OT Marcellus Johnson

Las Vegas Raiders

Los Angeles Chargers

New England Patriots

  • Signed: TE Marshall Lang
  • Released: DB Tyron Herring, TE Gee Scott Jr.

Philadelphia Eagles

San Francisco 49ers

Tampa Bay Buccaneers

Washington Commanders

  • Released: G Tyler Cooper

With Anthony Richardson heading to injured reserve with an eye injury, the Colts are set to add some QB depth in veteran Brett Rypien, per ESPN’s Jeremy Fowler. The 29-year-old brings four games of starting experience to Indy, with his most recent start coming with the Rams in 2023. In total, Rypien has completed 58.3 percent of his career passes for 950 yards, four touchdowns, and nine interceptions. Riley Leonard will temporarily be the QB2 behind Daniel Jones, but there’s a chance Rypien eventually works his way up to the active roster.

The Chargers moved on from a notable edge defender today in Clelin Ferrell. The former Raiders first-round pick started all 17 games for the 49ers just two years ago, with the edge rusher finishing that campaign with 3.5 sacks and 13 QB hits. He started 10 of his 14 appearances with the Commanders in 2024, adding another 3.5 sacks to his resume. After being among Washington’s final preseason cuts, Ferrell caught on with the Chargers practice squad and ended up getting into one game with the big-league club.

The Eagles moved on from a pair of skill players today. Audric Estime was a fifth-round pick by the Broncos last year, with the running back compiling 337 yards from scrimmage and two touchdowns on 81 touches. He was waived by Denver back in August and landed on Philly’s practice squad. Javon Baker was a fourth-round pick by the Patriots in last year’s draft, but he was limited to a single catch in 11 games.

49ers’ George Kittle Has Chance At Week 7 Return; November Reemergence Targeted For Brandon Aiyuk

October 14th, 2025 at 2:51pm CST by Sam Robinson

Once again battered by injuries, the 49ers have still managed to reach 4-2 despite a spree of setbacks for the second straight season. Pro Bowlers Brock Purdy, George Kittle and Nick Bosa have missed time, and the Fred Warner loss deals a blow the team has not previously encountered.

On the team amid the 2020 and 2024 injury waves, Warner has missed one career game. The All-Pro linebacker has crafted a Hall of Fame-caliber resume during the 49ers’ Kyle Shanahan-era surge, but he will undergo surgery Wednesday and joins Bosa in being out for the season. The 49ers are eyeing trades on defense, but their offense is starting to look healthier (even if Jauan Jennings is playing through a significant rib injury).

[RELATED: 49ers Expected To Inquire On Trey Hendrickson Trade]

While Purdy’s status remains murky, Kittle is nearing a return. Shanahan does expect (via 49ers reporter Briana Jeannel) the All-Pro tight end will be designated for return from IR ahead of the Falcons matchup. This would allow the 49ers a ramp-up period, but Shanahan added (via NBC Sports Bay Area’s Matt Maiocco) the hope is Kittle returns for Week 7.

Although the 49ers’ injury trouble is again mounting, they are not in bad shape yet in terms of IR activations. The team has either seen key players suffer season-ending injuries (Bosa, Warner) or remain on the active roster in week-to-week setups (Purdy, Jennings, Ricky Pearsall). The 49ers did place starting guard Ben Bartch on IR, and he is eligible for activation this week. It is uncertain if Bartch will join Kittle in being designated for return.

Kittle went down with a hamstring injury in Week 1. The likely Hall of Fame-bound pass catcher suited up for 15 games last season and did not miss any time due to injury in 2023. Playing in at least 14 games in 2021 and ’22, Kittle has not missed this much time in a season since being part of the 49ers’ spate of maladies in 2020. He missed eight games that season, suffering a sprained knee and fractured foot during San Francisco’s 6-10 season.

With Pearsall on the active roster, the 49ers are moving closer to full strength after seeing both their top two receivers go down early this season. San Francisco’s true No. 1 receiver, however, remains on the reserve/PUP list. Brandon Aiyuk‘s timetable has been pushed back a bit. Week 6 was floated months ago as a loose return window, but that has come and gone. Shanahan has now mentioned Week 10 as an updated window (via Maiocco) but stopped short of providing a firm timetable.

Out since October 20, 2024 with an ACL tear, Aiyuk has been in rehab mode after the tear was not deemed clean. Joining Kittle in suffering an injury shortly after an offseason extension, Aiyuk has been unable to build on the second-team All-Pro season he produced in 2023. John Lynch said in late September the sixth-year veteran was “not close” returning, but Shanahan’s update does provide a semi-positive sign a reemergence near the midseason point is still in play.

Like the IR-return process, the 49ers would have a 21-day period to observe Aiyuk in practice before activating him. Given the length of Aiyuk’s rehab process, it would surprise if he suited up the week he was designated for return. It should be expected, based on this timeline, Aiyuk would be in the PUP-return window soon. But the 49ers will continue to make do with a ravaged receiver depth chart for the time being. Though, Kittle’s return will help the passing attack considerably while Aiyuk hits the recovery homestretch.

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