49ers Place WR Brandon Aiyuk On Reserve/Left Squad List
If there were any chance at reconciliation between the 49ers and wide receiver Brandon Aiyuk before today, it’s likely gone now. Today, San Francisco placed the former first-round pick on the reserve/left squad list, per Matt Maiocco of NBC Sports. As a result, he will be ineligible to play for the remainder of the season, making an offseason departure all the more likely. 
Aiyuk hasn’t played since tearing his right ACL, MCL, and meniscus in Week 7 of 2024. The injury came a couple of months after he signed a four-year, $120MM extension with the 49ers. The relationship between the two sides has fallen apart since then.
[RELATED: Aiyuk On Commanders’ Radar?]
Aiyuk didn’t attend offseason appointments to rehab his knee in the offseason, leading the 49ers to void his 2026 guarantees last July. And while Aiyuk had a 50-day window to file a grievance through the NFLPA, he didn’t take any action during that span. He lost out on over $26MM as a result.
Still recovering from last year’s injury, Aiyuk spent the season on the reserve/PUP list before today. Earlier this month, general manager John Lynch expressed hope that the team would open Aiyuk’s practice window at some point soon. Doing so would have given the playoff-contending 49ers 21 days to evaluate Aiyuk. That will not happen, though, and this will go down as a lost season for Aiyuk.
The placement on reserve/left squad list is a unique one, usually reserved for players who plan to retire or quit on their team. In addition to all of the money Aiyuk has already lost throughout this season-long saga, Jason Fitzgerald of Overthecap.com claims that the 49ers may be allowed to go after Aiyuk’s signing and option bonus money in the wake of how things have now played out.
There was already plenty of speculation that Aiyuk’s time in the Bay Area was coming to an end, but this all but confirms it. Whether through offseason trade or an outright release, it’s just hard to picture Aiyuk playing in red and gold again.
In addition to the transaction that effectively ended Aiyuk’s tenure in San Francisco, the 49ers also announced that linebacker Jalen Graham and defensive tackle Sebastian Valdez would serve as standard gameday practice squad elevations for tomorrow’s game. This will be Graham’s third and final elevation of the season. If the team wants to see him play in another game this year, they’ll need to sign him to the 53-man roster.
Connor Byrne contributed to this post.
Minor NFL Transactions: 11/29/25
Here are Saturday’s minor moves around the NFL, including gameday elevations for the remainder of Week 13:
Atlanta Falcons
- Elevated: WR Deven Thompkins
Buffalo Bills
- Activated from IR: OL Tylan Grable
- Elevated: TE Keleki Latu, LB Baylon Spector
Cleveland Browns
- Elevated: DT Sam Kamara
Houston Texans
- Elevated: CB Ameer Speed
- Placed on IR: CB Ajani Carter
Indianapolis Colts
- Elevated: DE Chris Wormley
Jacksonville Jaguars
- Elevated: DE Matt Dickerson, S Cam’Ron Silmon-Craig
Las Vegas Raiders
- Elevated: OL Atonio Mafi, CB Greedy Vance
Los Angeles Chargers
- Signed from practice squad: RB Jaret Patterson
- Waived: OL Foster Sarell
- Elevated: RB Trayveon Williams
Minnesota Vikings
- Elevated: CB Dwight McGlothern Jr., QB John Wolford
New York Jets
- Elevated: DE Eric Watts, DB Jordan Clark
San Francisco 49ers
- Elevated: K Matt Gay, LB Jalen Graham
Seattle Seahawks
- Signed from practice squad: RB Myles Gaskin
- Placed on IR: RB George Holani
- Elevated: S Quandre Diggs, RB Velus Jones
Tampa Bay Buccaneers
- Signed from practice squad: QB Connor Bazelak
- Waived: RB Owen Wright
- Elevated: S Marcus Banks
Tennessee Titans
- Elevated: WR Xavier Restrepo, CB Kemon Hall
The Vikings brought back Desmond Ridder as quarterback insurance with J.J. McCarthy concussed. Ridder joined the team’s practice squad, and he will not dress for Minnesota tomorrow. Instead, it will be Wolford handling backup duties while undrafted rookie Max Brosmer makes his first career start.
Diggs returned to Seattle earlier this week. The veteran will receive the opportunity to play right away during his second stint with the Seahawks. Diggs earned three Pro Bowl nods during his first run in Seattle, and he will look to provide depth in the secondary with a familiar team down the stretch.
Minor NFL Transactions: 11/24/25
Today’s minor moves:
Buffalo Bills
- Practice window opened: OL Tylan Grable
Carolina Panthers
- Elevated: LB Krys Barnes, RB DeeJay Dallas
Cincinnati Bengals
- Waived: QB Sean Clifford
Los Angeles Rams
- Waived: S Tanner Ingle
San Francisco 49ers
- Elevated: K Matt Gay, LB Jalen Graham
The Bills should soon get some extra OL depth, as Grable returned to practice today. The former sixth-round pick landed on IR before the start of the season thanks to concussion symptoms, and that ended up keeping him off the practice field for months. Now, the Bills will have 21 days to consider adding the second-year player to the active roster. As a rookie in 2024, the UCF product got into four games (one start).
Wednesday NFL Transactions: NFC West
Following the 53-man roster cutdown deadline Tuesday, many teams will make slight tweaks to their rosters. In addition to waiver claims, teams can begin constructing their 16-man practice squads today. These 49ers, Cardinals, Rams and Seahawks moves are noted below.
Arizona Cardinals
Signed to practice squad:
- WR Andre Baccellia, LB Elliott Brown, OL Jeremiah Byers, RB Michael Carter, OL Jake Curhan, TE Josiah Deguara, WR Simi Fehoko, DL Anthony Goodlow, CB Darren Hall, OL Sincere Haynesworth, OL Nick Leverett, T Roy Mbaeteka WR Tejhaun Palmer, DL Elijah Simmons
Los Angeles Rams
Signed to practice squad:
- OL A.J. Arcuri, OL Wyatt Bowles, WR Tru Edwards, CB A.J. Green, DT Jack Heflin, S Tanner Ingle, CB Cam Lampkin, OL Dylan McMahon, OLB Jamil Muhammad, ILB Elias Neal, DT Bill Norton, WR Brennan Presley, TE Mark Redman, RB Ronnie Rivers, RB Cody Schrader, S Nate Valcarcel
San Francisco 49ers
Signed:
- WR Russell Gage
Claimed:
- DT Jordan Jefferson (from Jaguars)
Released from IR (via settlement):
- RB Corey Kiner
Signed to practice squad:
- CB Eli Apple, WR Junior Bergen, DL William Bradley-King, DB Derrick Canteen, WR Robbie Chosen, DL Trevis Gipson, LB Jalen Graham, OL Drake Nugent, LB Curtis Robinson, WR Malik Turner, DL Sebastian Valdez, TE Brayden Willis, OL Nick Zakelj
Seattle Seahawks
Signed:
Claimed:
- CB Derion Kendrick (from Rams)
Released:
Signed to practice squad:
- DT Quinton Bohanna, WR Tyrone Broden, DT Anthony Campbell, DE Jalan Gaines, WR Courtney Jackson, CB Shemar Jean-Charles, T Amari Kight, G Sataoa Laumea, C Federico Maranges, QB Adrian Martinez, RB Damien Martinez, LB Patrick O’Connell, NT Brandon Pili, S Jerrick Reed, LB Jamie Sheriff, DT J.R. Singleton, RB Anthony Tyus III, WR Ricky White, RB Jacardia Wright
49ers Cut 25 Players, Set 53-Man Roster
The 49ers had some work to do to get down to their initial 53-man roster. The front office achieved that daunting task this afternoon, as the organization announced the following moves:
Released:
- WR Robbie Chosen
- OL Michael Dunn
- WR Russell Gage
- DL Jonathan Garvin
- DL Trevis Gipson
- DL Bruce Hector
- WR Isaiah Hodgins
- CB Fabian Moreau
- P Thomas Morstead
- LB Curtis Robinson
- LB Chazz Surratt
- WR Malik Turner
- RB Jeff Wilson
Waived:
- WR Junior Bergen
- LB Stone Blanton
- DL William Bradley-King
- DB Derrick Canteen
- CB Dallis Flowers
- LB Jalen Graham
- S Jaylen Mahoney
- OL Drake Nugent
- WR Terique Owens
- DL Sebastian Valdez
- TE Brayden Willis
- OL Nick Zakelj
Activated from active/PUP:
- DL Yetur Gross-Matos
Placed on reserve/PUP:
- WR Brandon Aiyuk
- S Malik Mustapha
Placed on reserve/NFI:
- QB Kurtis Rourke
Placed on reserve/suspended:
- OL Isaac Alarcon
- WR Demarcus Robinson
Placed on IR (designated for return):
- DL Kevin Givens
Placed on IR:
- CB Jakob Robinson
Punter Thomas Morstead was cut today, but it sounds like the veteran won’t be a free agent for long. Matt Barrows of The Athletic reports that Morstead is expected to re-sign with the organization. The 39-year-old spent the past two seasons with the Jets, including a 2023 campaign where he led the NFL in punts and punting yards.
Barrows also notes that Jacob Cowing made the initial roster but is expected to land on injured reserve as he nurses a hamstring injury. This could open the door for one of the team’s cut WRs to land back on the active roster. That grouping includes Russell Gage, who had more than 1,500 receiving yards for the Falcons between the 2020 and 2021 seasons.
Elsewhere on offense, Jeff Wilson‘s reunion with the 49ers proved to be short lived after he joined the organization earlier this month. The veteran spent the past two-plus seasons in Miami, but he had a successful run in San Francisco to begin his career. This included a 2020 campaign where he compiled 733 yards from scrimmage and 10 touchdowns.
Minor NFL Transactions: 4/22/25
Here are Tuesday’s minor moves:
Detroit Lions
- Re-signed: OL Michael Niese
Minnesota Vikings
- Waived: OL Trevor Reid
Pittsburgh Steelers
- Signed second-round RFA tender: RB Jaylen Warren
San Francisco 49ers
- Signed ERFA tender: DL Evan Anderson, DL Alex Barrett, LB Jalen Graham, TE Brayden Willis
The Steelers let Najee Harris walk in free agency, passing on re-signing their four-year starting RB despite the Chargers only giving him a one-year, $5.25MM deal. That base value is nearly identical to Warren’s 2025 compensation, set for $5.35MM by virtue of being tendered at the second-round level.
A former UDFA, Warren has served as Harris’ flashier sidekick for three seasons. The former Utah State and Oklahoma State back has proven a find, making key contributions off the bench while on a UDFA deal. Warren, 26, totaled 1,154 scrimmage yards in 2023 and 821 (in 15 games) last year. He will be set to team with Kenneth Gainwell, who is also on a one-year agreement. Pittsburgh has since been linked to adding a starter-level RB in the draft.
RFA/ERFA Tender Decisions: 2/18/25
Tuesday’s free agent tender decisions:
ERFAs
Tendered:
- 49ers: DT Evan Anderson, DE Alex Barrett, LB Jalen Graham, DE Sam Okuayinonu, T Austen Pleasants, TE Jake Tonges, TE Brayden Willis
The 49ers made the decision today to tender all of their exclusive rights free agents today. The move restricts the seven players from negotiating with other teams. The players will have the choice to accept the offer and play for the 49ers or not play football in 2025.
San Francisco also has two restricted free agents: linebacker Curtis Robinson and running back Jordan Mason. It is yet to be seen what the team will do with those players who, if tendered, would be allowed to negotiate with other teams but would have to give the 49ers the chance to match any offer.
Minor NFL Transactions: 12/21/24
Today’s minor transactions and standard gameday practice squad elevations:
Arizona Cardinals
- Elevated: T Jackson Barton, RB Michael Carter
Atlanta Falcons
- Signed to active roster: WR Chris Blair
- Elevated: WR Dylan Drummond
- Waived: LB Rashaan Evans
Buffalo Bills
- Elevated: S Kareem Jackson, WR Jalen Virgil
Carolina Panthers
- Elevated: RB Mike Boone, T Brandon Walton
Chicago Bears
- Signed to active roster: RB Darrynton Evans
- Placed on IR: G Ryan Bates
Cincinnati Bengals
- Elevated: DE Isaiah Thomas
Cleveland Browns
- Elevated: CB Kahlef Hailassie, WR James Proche
Dallas Cowboys
- Signed to active roster: CB Andrew Booth
- Elevated: LB Darius Harris, T Dakoda Shepley
- Placed on IR: CB Trevon Diggs (story)
Detroit Lions
- Activated from IR: S Ifeatu Melifonwu
- Signed to active roster: OLB Mitchell Agude, WR Tom Kennedy, DL Chris Smith
- Elevated: RB Jermar Jefferson, S Loren Strickland
- Waived (via injury settlement): DT David Bada
- Waived: WR Maurice Alexander
Las Vegas Raiders
- Signed to active roster: CB Kyu Blu Kelly
- Elevated: TE John Samuel Shenker
Los Angeles Rams
- Elevated: CB Charles Woods
Miami Dolphins
- Activated from reserve/PUP: LB Cameron Goode
- Elevated: WR Erik Ezukanma
- Waived: DT Neil Farrell
Minnesota Vikings
- Elevated: S Bobby McCain, TE Nick Muse
New England Patriots
- Signed to active roster: RB Terrell Jennings
- Elevated: WR Alex Erickson, LB Monty Rice
New York Giants
- Signed to active roster: DB Raheem Layne
- Elevated: OLB Boogie Basham, T Tyre Phillips
New York Jets
- Elevated: DT Bruce Hector, S Jarius Monroe
Philadelphia Eagles
- Elevated: FB Khari Blasingame
San Francisco 49ers
- Signed to active roster: LB Jalen Graham, T Austen Pleasants
- Elevated: DT Alex Barrett, RB Ke’Shawn Vaughn
- Waived: T Sebastian Gutierrez
Seattle Seahawks
- Signed to active roster: QB Jaren Hall
- Elevated: CB Artie Burns
- Placed on IR: OLB Trevis Gipson
Tampa Bay Buccaneers
- Elevated: P Jack Browning
Washington Commanders
- Elevated: DT Carl Davis
After being activated from injured reserve in early November, Bates only played two games before suffering a concussion. The 27-year-old has not played since Week 11 and will now miss the remainder of the season on IR. Bates is under contract through 2025.
49ers Activate S Talanoa Hufanga
The 49ers have been bombarded with injuries this year, but today they’ll get a bit of relief. San Francisco has officially made the move to activate safety Talanoa Hufanga from injured reserve. After attempting to make a comeback earlier this year, the hope is that, this time, Hufanga will be healthy enough and here to stay. 
Hufanga’s initial return was from a torn ACL that he suffered just over a year ago. The team activated him from the active/PUP list just prior to the start of the regular season to ensure that he wouldn’t miss the first four games of the year. A limited runup to the season meant a limited snap share when he finally did return to the lineup, though, and after missing the first two games of the season, Hufanga made his official return in Week 3.
Hufanga missed a game after his 2024 debut before getting his second start, but he left that second game early and did not return. In the process of his comeback, Hufanga had suffered ligament damage in his wrist, necessitating an unfortunate return to IR. There was seemingly no guarantee that he would return this season, but the team ended up opening his practice window earlier this week. Hufanga, who is in a contract year, will not be 100 percent in his return as he still needs support for his injured wrist. With a potential free agency run coming, though, Hufanga will attempt to give it a go.
In order to make room on the 53-man roster for Hufanga, the Niners officially made the move to place running back Jordan Mason on IR. Joining Mason on IR will be backup safety George Odum, who has missed the past week of practice dealing with a knee issue that will seemingly end his season.
With an additional roster spot being made available, San Francisco will sign practice squad offensive tackle Sebastian Gutierrez to the active roster. Signed to the practice squad last week after some time in Indianapolis, Gutierrez was elevated for last weekend’s contest but hasn’t appeared in a game since 2022.
Joining Gutierrez for gameday from the practice squad will be linebacker Jalen Graham and running back Ke’Shawn Vaughn. As standard practice squad elevations, Graham and Vaughn will revert to the practice squad after the game, while Gutierrez will remain on the 53-man roster.
Minor NFL Transactions: 11/30/24
Saturday’s minor moves and standard gameday practice squad elevations:
Atlanta Falcons
- Elevated: K Riley Patterson, LB Josh Woods
Baltimore Ravens
- Elevated: LB William Kwenkeu, DE Chris Wormley
- Placed on IR: TE Charlie Kolar (story), CB Arthur Maulet
Carolina Panthers
- Activated from reserve/PUP: OLB Amaré Barno
- Elevated: WR Dan Chisena, TE Stephen Sullivan
- Waived: OLB Thomas Incoom
Cleveland Browns
- Signed to active roster: TE Blake Whiteheart
- Placed on IR: TE Geoff Swaim
Houston Texans
- Elevated: TE Irv Smith Jr., WR Jared Wayne
Indianapolis Colts
- Signed to active roster: G Atonio Mafi
- Elevated: G Mark Glowinski, WR Laquon Treadwell
- Waived: LB Liam Anderson
Jacksonville Jaguars
- Elevated: WR Elijah Cooks
Minnesota Vikings
- Elevated: TE Nick Muse, CB Nahshon Wright
New England Patriots
- Elevated: LB Keshawn Banks, G Michael Jordan
New Orleans Saints
- Signed to active roster: G Kyle Hergel
- Elevated: WR Kevin Austin, WR Dante Pettis
- Waived: S Millard Bradford
Philadelphia Eagles
- Signed to active roster: WR Parris Campbell
- Elevated: LB Ochaun Mathis, TE C.J. Uzomah
- Placed on IR: LB Ben VanSumeren (story)
San Francisco 49ers
- Signed to active roster: CB Nick McCloud
- Elevated: LB Jalen Graham, T Sebastian Gutierrez
Seattle Seahawks
- Elevated: QB Jaren Hall, S Ty Okada
Tampa Bay Buccaneers
- Elevated: QB Michael Pratt
Falcons kicker Younghoe Koo is listed as questionable, but head coach Raheem Morris is confident he’ll play, calling Patterson an emergency option.
Speculation out of Baltimore was that Maulet wouldn’t require a second stint on injured reserve with his calf injury, but that intel appears to have been off. Maulet and Kolar could potentially make a return in time for the postseason, but they’ll miss four games before they do.
VanSumeren served double-duty as a fullback and linebacker. With his placement on IR, Uzomah was targeted as a possibility to fill in at fullback.