49ers Activate Yetur Gross-Matos From IR
The 49ers’ edge rush group has received a boost in time for tonight’s game. Yetur Gross-Matos has been activated from injured reserve, per a team announcement. 
Gross-Matos returned to practice on December 10. He was not activated in time to play in Week 15, but enough progress has been made during the past few days for a return to action to take place tonight. The 27-year-old has been sidelined since Week 5 due to a hamstring injury.
When Gross-Maros aggravated the ailment, his return timeline was set back. That led to his IR placement and left the former second-rounder unavailable for an extended period. Getting him back in the fold will be a welcomed development on a San Francisco team which has been hit hard by injuries in 2025. The defensive end spot in particular has been thinned out over the course of the year.
Starters Nick Bosa and Mykel Williams are each recovering from ACL tears. Neither will be able to return in 2025, something which has led to the likes of Bryce Huff, Sam Okuayinonu and Clelin Ferrell taking on increased roles. The team was linked to Trey Hendrickson ahead of the trade deadline, but the only acquisition on that front was Keion White. Getting Gross-Matos back in the fold will provide depth along the edge, although the Penn State product has starting experience dating back to his Panthers tenure.
A 2024 free agent addition, Gross-Matos played 11 games during his debut San Francisco campaign. He notched four sacks in that span, the second-highest total of his career. Chipping in down the stretch and into the playoffs would be key for the 49ers; it would also help boost Gross-Matos’ value on the open market for 2026.
Given today’s move, San Francisco has three IR activations remaining for the regular season. The team will receive another two once the playoffs begin.
49ers To Designate DE Yetur Gross-Matos To Return From IR
The 49ers are designating defensive end Yetur Gross-Matos to return from injured reserve, per Matt Barrows of The Athletic.
Gross-Matos, 27, appeared in San Francisco’s first five games of the season before going down with a hamstring strain. He spent a few weeks on the shelf before re-aggravating the injury at the end of October. That forced the six-year veteran onto IR on November 1, and his absence has now extended to eight games.
The 49ers have been decimated by injuries this season on both sides of the ball, and their defensive end room has been no exception. All-Pro Nick Bosa and first-round rookie Mykel Williams are both out for the season, which, along with Matos’ injury, has forced the team to pivot. Bryce Huff and Sam Okuayinonu have stepped up to lead the position group in snaps with mid-season acquisitions Keion White and Clelin Ferrell also taking on rotational roles.
Those four are not churning out high-level production – the 49ers are last in the NFL with 16 sacks – but they have stopped the run effectively and contributed to some turnovers in the last few weeks. That has kept San Francisco in the NFC playoff picture through their Week 14 bye. Getting Gross-Matos back would at least add some depth to the team’s defensive line, though he did not have a great start to the year. He only logged four tackles and one quarterback hit before he got hurt, but at the time, he occupied a 27% snap share. There may be much more playing time available once he returns to the field.
Gross-Matos will have 21 days to practice with the team before he must be added to the active roster or revert to season-ending IR.
Mac Jones To Start Week 10; Latest On Other 49ers Injuries
Every week, there seems to be something injury-related coming out of the Bay Area. Whether it’s somebody preparing to miss a lot of time, a “will he” or “won’t he” gametime decision, or questions on timetables for return, the 49ers have provided headlines all season. The latest such headline pertains to the middle option as a questionable Brock Purdy will watch Mac Jones start for the sixth week in a row, per Tom Pelissero of NFL Network. 
It’s become a weekly post with Purdy, who has been on the team’s injury report every week since he was hurt in the season opener. The 25-year-old has been getting closer and closer to coming back, and head coach Kyle Shanahan communicated that he could still be active as a backup to Jones. Third-string passer Adrian Martinez was signed from the practice squad to the active roster back in October as Purdy was nearing a return back then, so with three quarterbacks on the 53-man, Purdy could either be a primary backup or an emergency third option.
The quarterback role we do know, though, will be Jones, who will start under center for the eighth time this year. After winning his first three starts as an injury replacement, Jones has cooled off, alternating losses and wins since then. Despite a largely injured supporting cast around him, Jones is averaging a career-high 261.7 passing yards per game while also sporting the best touchdown:interception ratio (10:5) of his career. He’ll be looking to buck the trend of alternating finishes after beating the Giants last week.
One player we know won’t be out there is wide receiver Ricky Pearsall. The second-year pass-catcher has been missing since Week 4 and is about to miss his sixth game in a row. Asked about what’s holding Pearsall from being able to play, Shanahan told the media that “he hasn’t been able to hit his normal speeds that would allow him to come back,” per Cam Inman of the Bay Area News Group. Reporters noted the young wideout had been sighted doing sprints at practices and shooting jump shots in the locker room, but Shanahan was adamant that the team is waiting for Pearsall to be able to hit his old marks.
Pearsall isn’t the only receiver unavailable this week. Veteran wideout Brandon Aiyuk remains on the reserve/PUP list ten weeks into the season. November was offered up last month as a potential return window for the 27-year-old receiver. It’s now been over a year since Aiyuk has appeared in a game, and each week, expectations for Aiyuk’s 21-day practice window to be opened go unrealized. Shanahan continues to seem vaguely optimistic, with Vic Tafur of The Athletic quoting him as “pretty confident” that Aiyuk will be back sometime this season.
Given the extended absences of players like Purdy and Pearsall, among some others, there have been questions on why players missing so much time weren’t put on injured reserve. According to The Athletic’s Matt Barrows, the primary reason is simply that they didn’t expect each player to be out for so long. Additionally, while the NFL has implemented the current system wherein teams can bring players back from IR, each team is only given eight such activations.
Lucky teams can put players with minor injuries on IR and activate them four weeks later just to manipulate roster numbers. With so many injuries week in and week out, the 49ers likely would’ve loved to place guys on IR so they could add healthy reinforcements to the roster. Knowing how many impact players they had already placed on IR, though, San Francisco needed to be weary of how it would be able to utilize its limited activations.
One player that did land on IR recently was edge rusher Yetur Gross-Matos. Gross-Matos had been out since Week 5 and was expected to make a return soon. Unfortunately, the 27-year-old defender strained his hamstring again near the end of last week, per ESPN’s Nick Wagoner. While it will take Gross-Matos some time to work his way back from the injury, Shanahan doesn’t believe he will be sidelined for the remainder of the season.
Minor NFL Transactions: 11/1/25
Here are today’s minor moves and practice squad callups for the ninth weekend of the NFL season:
Atlanta Falcons
- Elevated: WR Dylan Drummond
Buffalo Bills
- Elevated: CB Dane Jackson, DT Phidarian Mathis
Chicago Bears
- Elevated: RB Brittain Brown
Cincinnati Bengals
- Elevated: LB Brian Asamoah II, G Jaxson Kirkland
Denver Broncos
- Elevated: WR Michael Bandy, TE Marcedes Lewis
Detroit Lions
- Elevated: LB Ty Summers
Green Bay Packers
- Signed from practice squad: LB Kristian Welch
- Elevated: DE Arron Mosby
- Placed on IR: LB Nick Niemann
Indianapolis Colts
- Elevated: DE Durell Nchami, WR Laquon Treadwell
Jacksonville Jaguars
- Elevated: LB Branson Combs, WR Tim Jones
Kansas City Chiefs
- Elevated: RB Clyde Edwards-Helaire, G C.J. Hanson
Las Vegas Raiders
- Elevated: CB Greedy Vance
Los Angeles Chargers
- Elevated: RB Amar Johnson, RB Jaret Patterson
- Placed on IR: RB Hassan Haskins
Los Angeles Rams
- Elevated: CB A.J. Green, RB Ronnie Rivers
Minnesota Vikings
- Elevated: CB Fabian Moreau, TE Nick Vannett
New England Patriots
- Elevated: RB D’Ernest Johnson
New Orleans Saints
- Elevated: LB Eku Leota
New York Giants
- Activated from IR: CB Rico Payton
- Elevated: LB Zaire Barnes, WR Ray-Ray McCloud
- Placed on IR: CB Art Green
Pittsburgh Steelers
- Activated from IR: LB Malik Harrison
- Elevated: RB Lew Nichols, RB Trey Sermon
San Francisco 49ers
- Activated from IR: OL Spencer Burford
- Elevated: DE Clelin Ferrell, OL Nick Zakelj
- Placed on IR: OLB Yetur Gross-Matos
Tennessee Titans
- Elevated: WR James Proche, DT Carlos Watkins
Washington Commanders
- Elevated: WR Treylon Burks, DT Sheldon Day
The Steelers are getting Harrison back at a crucial time. Fellow linebacker Cole Holcomb has been ruled out this weekend with an illness — as has safety Chuck Clark, per Ian Rapoport of NFL Network — and Harrison should be able to reinforce the group. He has plenty of experience playing next to starter Patrick Queen from their time together in Baltimore, so perhaps he’ll be able to step in and contribute right away.
The Chargers continue to see their running backs room plagued with injury. Haskins joins Omarion Hampton and Najee Harris on injured reserve. Johnson and Patterson will suit up tomorrow to provide some depth behind lone survivor Kimani Vidal.
With Terry McLaurin once again set to miss time, Burks, the newly signed p-squad addition, will make his Washington debut. Also a newly signed p-squad addition, Lewis will make his Denver debut this weekend. If he sees game time, 2025 will officially be Lewis’ 20th season in the NFL.
After missing the last three games, Gross-Matos appeared to be close to returning to play. According to Matt Maiocco of NBC Sports, the 27-year-old re-injured his hamstring at practice on Thursday and will now miss another four games.
For Leota in New Orleans, Mosby in Green Bay, Sermon in Pittsburgh, Zakelj in San Francisco, and both Proche and Watkins in Tennessee, this Sunday will be their third and final standard gameday practice squad elevation on their current deals. In order to appear in any more games after this, their respective teams will need to sign them to the active roster.
Latest On 49ers’ Injuries
San Francisco is one of a few teams that have been bitten especially hard by the injury bug this season. Luckily, they’ve avoided the injury to their star running back that had everyone worried about to start the year, but in a crucial divisional matchup last night, the 49ers’ injury report ruled out five players, including the starting quarterback and three wide receivers. 
San Francisco was able to pull out a victory in last night’s game despite the team that’s taken so many hits thus far taking a few more in Los Angeles. The successful trip saw injuries sustained by defensive tackles Kalia Davis, Yetur Gross-Matos, and rookie Alfred Collins, as well as rookie cornerback Upton Stout, according to Nick Wagoner of ESPN. The only one who appears to have gotten off easy is Stout, who avoided a high ankle sprain, just suffered a regular ankle sprain, and is currently day-to-day.
Davis, on the other hand, will require surgery to repair a broken bone in his hand. Per Ian Rapoport of NFL Network, the procedure was scheduled to take place today. There’s some thought that Davis could potentially miss as few as two games. As a defensive lineman, Davis doesn’t have too much use for the gripping mechanic of that appendage in a game, and some expect him to return to play with a club cast on his hand.
Gross-Matos had just come off his only full practice of the week as he worked his way back from a knee injury. While the knee seemingly held up last night, Gross-Matos is now set to miss time with a hamstring strain, which could mean a multi-week absence. The rookie, Collins, suffered a sprained knee. With the Thursday Night Football matchup allowing for a bit more time to recover before their next game, Collins may stand a chance at not missing time, depending on the severity of the sprain.
Lastly, while we knew that star tight end George Kittle would be eligible to return from injured reserve in Week 6 after being placed on list after the season opener, we’ve finally received some insight on a more specific timeline. Per Vic Tafur of The Athletic, head coach Kyle Shanahan informed the media that Kittle likely will not be able to make it back until at least Week 7. At best, this will limit the veteran in-line pass catcher to a five-game absence.
49ers Cut 25 Players, Set 53-Man Roster
The 49ers had some work to do to get down to their initial 53-man roster. The front office achieved that daunting task this afternoon, as the organization announced the following moves:
Released:
- WR Robbie Chosen
- OL Michael Dunn
- WR Russell Gage
- DL Jonathan Garvin
- DL Trevis Gipson
- DL Bruce Hector
- WR Isaiah Hodgins
- CB Fabian Moreau
- P Thomas Morstead
- LB Curtis Robinson
- LB Chazz Surratt
- WR Malik Turner
- RB Jeff Wilson
Waived:
- WR Junior Bergen
- LB Stone Blanton
- DL William Bradley-King
- DB Derrick Canteen
- CB Dallis Flowers
- LB Jalen Graham
- S Jaylen Mahoney
- OL Drake Nugent
- WR Terique Owens
- DL Sebastian Valdez
- TE Brayden Willis
- OL Nick Zakelj
Activated from active/PUP:
- DL Yetur Gross-Matos
Placed on reserve/PUP:
- WR Brandon Aiyuk
- S Malik Mustapha
Placed on reserve/NFI:
- QB Kurtis Rourke
Placed on reserve/suspended:
- OL Isaac Alarcon
- WR Demarcus Robinson
Placed on IR (designated for return):
- DL Kevin Givens
Placed on IR:
- CB Jakob Robinson
Punter Thomas Morstead was cut today, but it sounds like the veteran won’t be a free agent for long. Matt Barrows of The Athletic reports that Morstead is expected to re-sign with the organization. The 39-year-old spent the past two seasons with the Jets, including a 2023 campaign where he led the NFL in punts and punting yards.
Barrows also notes that Jacob Cowing made the initial roster but is expected to land on injured reserve as he nurses a hamstring injury. This could open the door for one of the team’s cut WRs to land back on the active roster. That grouping includes Russell Gage, who had more than 1,500 receiving yards for the Falcons between the 2020 and 2021 seasons.
Elsewhere on offense, Jeff Wilson‘s reunion with the 49ers proved to be short lived after he joined the organization earlier this month. The veteran spent the past two-plus seasons in Miami, but he had a successful run in San Francisco to begin his career. This included a 2020 campaign where he compiled 733 yards from scrimmage and 10 touchdowns.
NFL Injury Updates: Fisher, 49ers, Samuel
Texans right tackle Blake Fisher is dealing with a mild ankle sprain that will sideline him for an indeterminate amount of time, according to KRPC2’s Aaron Wilson.
Fisher suffered the injury in last Saturday’s preseason matchup against the Panthers and missed practice this week. His absence, if it extends into the regular season, will add another wrinkle to Houston’s plans at tackle.
The Texans already overhauled the position this offseason. They traded Laremy Tunsil to the Commanders and replaced him by aqcuiring Cam Robinson from the Vikings. Houston also signed veteran Trent Brown in free agency and drafted Aireontae Ersery in the second round of April’s draft. Along with Fisher and Tytus Howard, who combined to play every snap at right tackle in 2024, the Texans have a variety of options on either end of their offensive line.
Robinson returned to the field this week after missing a few practices with a minor leg injury. He has been splitting first-team LT reps with Ersery. The rookie has been cross-training at right tackle as well, but only lined up on the blind side during the preseason. With Brown still on the physically unable to perform list, Howard has been playing right tackle in camp and sat out both preseason games, suggesting he will start in Week 1. Fisher started both preseason games at right tackle; if his ankle has recovered by the start of the regular season, he’ll likely be the Texans’ swing tackle.
As teams prepare to finalize their initial 53-man rosters by the Tuesday deadline, here is the latest from the injury front:
- 49ers head coach Kyle Shanahan said (via ESPN’s Nick Wagoner) that defensive end Yetur Gross-Matos may start the season on the PUP list as he recovers from a knee injury. San Francisco has been hoping that the five-year veteran could get back on the field during training camp, but it now appears that his absence will extend into the regular season.
- Eagles backup quarterback Tanner McKee injured his finger on Monday and missed practice for the rest of the week. He won’t need surgery, per Jeff Neiburg of the Philadelphia Inquirer, but head coach Nick Sirianni could only offer a “we’ll see” when asked about McKee’s status for Week 1.
- Free agent cornerback Asante Samuel Jr. visited multiple teams this offseason with repeated links to the Dolphins given their lack of cornerback depth. However, one of Samuel’s agents “declined to say Sunday whether he has been cleared medically from a neck injury,” according to Barry Jackson of the Miami Herald.
- Steelers rookie defensive tackle Derrick Harmon had an injury scare on Thursday night, but the first-round pick will not go on IR and may only miss one game, according to Gerry Dulac of the Pittsburgh Post Gazette.
Minor NFL Transactions: 7/18/25
Here are today’s minor NFL transactions as we head into the weekend:
Detroit Lions
- Signed: CB Dicaprio Bootle, CB Tyson Russell, RB Jabari Small
Green Bay Packers
- Placed on active/PUP: DE Collin Oliver, CB Micah Robinson, LB Quay Walker, WR Christian Watson (story), G John Williams
- Placed on active/NFI: K Alex Hale, C Elgton Jenkins, RB Amar Johnson
- Waived: DT Nesta Jade Silvera, DT Cameron Young
San Francisco 49ers
- Placed on active/PUP: WR Brandon Aiyuk (story), T Andre Dillard, DE Yetur Gross-Matos, S Malik Mustapha (story), WR Ricky Pearsall (story), LB Curtis Robinson
- Placed on active/NFI: OL Ben Bartch, S George Odum
The Lions have added three players to the roster today after a working them out. Bootle has had a cup of coffee with a few teams in the league after going undrafted in 2021. Small didn’t see the field at all as an undrafted rookie with the Titans last year, and Russell becomes the latest undrafted rookie free agent to sign a deal this year. His tenacity has been rewarded two and a half months after the draft.
49ers Rumors: CMC, Kittle, Williams, Dobbs
After shaking off injury trouble for two seasons, en route to staking a claim as the NFL’s best running back, Christian McCaffrey saw two issues create a lost season for him in 2024. The superstar back missed much of the season with an Achilles injury, and a PCL malady sustained in Buffalo sidelined him not long after he debuted. McCaffrey, who is going into his age-29 season, landed more guaranteed money via another market-setting extension (two years, $38MM), protecting himself for the 2025 season. The 49ers also expect their RB starter to be back by training camp and perhaps before, with John Lynch indicating (via The Athletic’s Matt Barrows) the ninth-year veteran will probably be ready for part of the team’s offseason program.
Not that McCaffrey needs to log much offseason participation, as this will be Year 4 for him in Kyle Shanahan‘s offense, but it would be an encouraging sign for a player who totaled only 50 carries last season. McCaffrey also saw injuries significantly limit him in 2020 and ’21 while in Carolina, but he played 17 games in 2022 and 16 in ’23, not missing any due to injury. The 49ers will hope the 2023 Offensive Player of the Year can return to that form in ’25.
Here is the latest out of San Francisco:
- As another 49ers NFC title defense could not navigate a rash of injuries, Trent Williams became part of the unavailable contingent. The future Hall of Fame left tackle missed the final seven games of San Francisco’s season with an ankle injury. Lynch confirmed (via Barrows) what had been expected, indicating Williams will be back for a 16th NFL season. Williams can break the tackle record for Pro Bowl invites by booking a 12th in 2025, which will be his age-37 season. Thanks to the contract adjustment he received to end a holdout, Williams would have brought more than $50MM in dead money had he retired after the 2024 slate.
- We heard Wednesday that the 49ers were talking not only with their top extension candidate, Brock Purdy, but with George Kittle as well. Staying mostly healthy over the course of his five-year, $75MM extension, the eight-year veteran — chosen in Lynch and Shanahan’s first draft — has put himself on the Hall of Fame radar. Lynch wants the star tight end to be a 49ers-only player during his career. “We want George to retire a Niner,” Lynch said. “He’s one of those guys — he’s a Niner through and through. So we want that to become a reality. I think the only thing on that is timing. And that’s no different than what I’ve told George and his agent.” The 49ers hammered out their first Kittle extension during training camp in 2020. Considering how this franchise usually conducts business, that is a timeframe to again monitor this year.
- An either/or path at defensive end may form regarding Nick Bosa‘s wingmen. Leonard Floyd and Yetur Gross-Matos are release candidates, Eric Branch of the San Francisco Chronicle writes. While Floyd has a track record as a sack artist, totaling at least nine each year from 2020-23, Gross-Matos received a surprising two-year, $18MM deal in 2024. The ex-Panthers second-rounder underwent in-season knee surgery and finished with four sacks in 11 games. That was a half-sack off his career high, however, but the 49ers having backloaded his deal would free up $7.82MM in a post-June 1 release. Using a post-June 1 designation on Floyd would free up $7.95MM in 2025 space but leave a bigger hole in the pass-rushing department. The 49ers have one June 1 move to make, as Javon Hargrave‘s release takes up the team’s other allotted slot.
- Josh Dobbs threw for 326 yards and two touchdowns during a meaningless Week 18 loss to the Cardinals, likely helping his cause for another QB2 deal. After losing the backup job to Brandon Allen, however, Dobbs is unlikely to re-sign with the 49ers, per Branch. When asked about a potential re-signing, Dobbs said recently, “Free agency is free agency.” If Allen is to reprise his 49ers QB2 role, he will need to be re-signed.
49ers Activate Yetur Gross-Matos, Place Mitch Wishnowsky On IR
NOVEMBER 16: As anticipated, both moves have now officially been made. San Francisco has four IR activations remaining on the year. The team’s playoff push will include another stint with one specialist on the sidelines, although the 49ers will have the option of bringing Wishnowsky back before the end of the regular season.
NOVEMBER 15: The 49ers are expected to activate defensive end Yetur Gross-Matos and place punter Mitch Wishnowsky on injured reserve with a back injury, according to ESPN’s Nick Wagoner.
Gross-Matos was placed on injured reserve on October 5 after suffering a knee injury that required surgery. He returned to practice on November 5 and is eligible to play against the Seahawks in Week 11. Wishnowsky will be sidelined for at least four weeks before he can be activated from IR.
Gross-Matos was a full participant in practice this week, but is still listed as questionable on the injury report since he has not officially been activated yet. The 49ers will be hoping Gross-Matos can play if Nick Bosa is sidelined with a hip injury, though he returned to practice on Friday after missing Tuesday and Wednesday. Bosa is questionable for Sunday’s game.
Wishnowsky’s injury leaves the 49ers down yet another specialist this year. Jake Moody missed a month with a high ankle sprain, and his replacement, Matthew Wright, landed on injured reserve with a shoulder injury. Anders Carlson then filled in for two games before Moody returned in Week 9.
The 49ers signed former Bears and Packers punter Pat O’Donnell to their practice squad on Wednesday as insurance for Wishnowsky’s back. He will likely be elevated for the game on Sunday, though the 49ers will need to make another move to promote him to the active roster since Gross-Matos will likely be taking Wishnowsky’s spot on the 53.