Despite walking away with a win this weekend, the Cardinals gave up 328 passing yards to Bryce Young and the Panthers. One reason for that may have been injuries to top corners Garrett Williams, Max Melton, and rookie Will Johnson. Melton and Johnson look like they’ll be fine, but Williams has been placed on injured reserve, per Cardinals staff writer Darren Urban.

Defensive lineman L.J. Collier will reportedly join Williams on IR. A main contributor a year ago after starting 15 games in 2024, Collier has spent the first two weeks of the new season as more of a depth piece on the team’s newly revamped defensive line. The depth hurts, though, as they still await the debut of first-round defensive tackle Walter Nolen.

It’s an unfortunate loss for Arizona with Williams coming off a sophomore campaign in which Pro Football Focus (subscription required) rated him as the third-best cornerback in the NFL. Melton and Johnson are the team’s starting cornerbacks on the outside, while Williams is the primary nickelback of the Cardinals secondary.

It was a knee injury that Williams suffered on Sunday. The team didn’t go into specifics on the injury, but obviously, it’s enough to keep him off the field for at least four weeks. Cardinals head coach Jonathan Gannon didn’t seem too worried, though, claiming that both Williams and Collier could return at some point in the season. Melton was back at practice today and looked unbothered by his own knee injury, while Johnson didn’t practice today but will continue to be evaluated throughout the rest of the week.

In the meantime, fifth-round rookie Denzel Burke stepped up in a big way in his debut on the team’s defense — Burke played only on special teams in Week 1. Third-year corner Kei’Trel Clark saw an increase in snap count, as well. Clark probably has the best chance to fill the slot cornerback role of Williams’. In extremely limited playing time last season, Clark spent about 39 percent of his time in the slot.

Another option to compete for the nickel role is Darren Hall, who was called up from the practice squad to take Williams’ spot on the active roster. Two more practice squad slots were made vacant when defensive tackle Elijah Simmons was signed to Tampa Bay’s active roster and linebacker Elliott Brown was released. Filling the three newly vacant slots are defensive tackle Zachary Carter, defensive tackle Kyon Barrs, and cornerback Ekow Boye-Doe.