The 49ers dealt with a number of major injuries over the course of the 2025 campaign. One of those was the ACL tear suffered by Mykel Williams, and his ability to start next season remains in question.
Williams’ rookie campaign ended in Week 9 when his ACL was torn. The No. 11 pick in last year’s draft had operated as a full-time starter up to that point, and a large workload can be expected once he is back on the field. 49ers GM John Lynch previously said a return at some point during training camp is likely in this case, and that still holds true.
As noted by The Athletic’s Matt Barrows, Williams remains on course to participate in at least a portion of training camp this summer. However, it is unclear at this time if the Georgia product will be able to play in Week 1. It would come as no surprise if Williams were to begin camp on the active/PUP list, something which could lead to a reserve/PUP designation during roster cuts. The latter would ensure at least a four-game absence to start the regular season.
Williams, 22 in June, was working out separate to the rest of the team during rookie minicamp, per Barrows. He adds clearance for full team drills should not be expected any time soon. The progress Williams makes over the coming months will be worth monitoring closely given his importance to San Francisco’s defense and also the fact fellow defensive end Nick Bosa is recovering from an ACL tear of his own. Bosa’s recovery timeline is further ahead, but a return to action in both cases will be critical to the 49ers’ 2026 outlook.
2025 trade acquisition Keion White, third-year 49er Sam Okuayinonu and free agent signing Cameron Sample are among the candidates to take on an increased workload early in the season provided Williams is unable to play right away in the fall. That is also true of rookie Romello Height, taken in the third round of April’s draft. In any event, development in Williams’ case after he managed just one sack and four quarterback pressures as a rookie will be key.
The 49ers currently lead the league with nearly $70MM in cap space, so a low-cost free agent signing could receive consideration if Williams and/or Bosa suffer setbacks in their rehabs. For now, though, those two are on course to operate as starters upon returning to action.