Star tight end George Kittle has been on IR since Sept. 9, but he’s finally nearing a return. The 49ers opened Kittle’s practice window on Wednesday, according to Clayton Holloway of NFL Network. They’ll have 21 days to activate him.
Kittle, who suffered a hamstring injury in a Week 1 win over the Seahawks, will practice on a limited basis on Wednesday. Head coach Kyle Shanahan said that quarterbacks Brock Purdy and Mac Jones will join Kittle as limited participants (via Matt Barrows of The Athletic).
Purdy, out back-to-back games with a toe injury, is viewed as more limited than Jones. While Jones is battling knee and oblique issues, he could make his third straight start Sunday against the Falcons.
Kittle has already missed five games this season, which is the second-highest total of his nine-year career. The six-time Pro Bowler entered 2025 off four consecutive seasons of at least 14 games played. He continued to thrive during a 15-game slate in 2024, catching 78 passes for 1,106 yards and eight touchdowns.
The 49ers were likely expecting more of the same from Kittle this season. Instead, he has been among many high-profile injury casualties for the club. San Francisco’s offense has gotten one appearance from Kittle, two from Purdy, and none from receiver Brandon Aiyuk. On the other side of the ball, the team has seen heart-and-soul defenders Fred Warner and Nick Bosa go down with season-ending injuries in recent weeks. Despite that, the 49ers have gotten off to a 4-2 start.
Without Kittle, the 49ers have turned to the little-known Jake Tonges as their primary tight end. To Tonges’ credit, he has done well filling in for Kittle. He entered the season with no catches over four games (all with Chicago in 2022), but Tonges has racked up 25 receptions, 34 targets, 224 yards, and three scores in six contests this year. He’ll serve as a solid No. 2 option at tight end when Kittle is back in the lineup, perhaps as early as this week.
The 49ers could also get Aiyuk back soon, which will further bolster their offense down the stretch as they vie for a playoff berth. Facing a fellow NFC postseason contender this week in the 3-2 Falcons, the 49ers may again have to overcome a Purdy absence. After signing a five-year, $265MM contract extension in the offseason, Purdy has been sidelined for most of 2025. Jones has held his own as a fill-in, but thanks in part to his own injury troubles, he struggled in a loss to the Buccaneers in Week 6.