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NFL Practice Squad Updates: 10/21/25

October 21st, 2025 at 8:38pm CST by Ben Levine

Today’s practice squad moves:

Atlanta Falcons

  • Signed: OL Raiqwon O’Neal
  • Placed on IR: OL Ryan Hayes

Carolina Panthers

Chicago Bears

Denver Broncos

  • Signed: OL Marques Cox
  • Released: OL Karsen Barnhart

Detroit Lions

Indianapolis Colts

  • Signed: DE Seth Coleman
  • Released: CB Keenan Garber

Los Angeles Chargers

New Orleans Saints

New York Giants

New York Jets

  • Signed: DT Fatorma Mulbah

Philadelphia Eagles

Pittsburgh Steelers

San Francisco 49ers

Tennessee Titans

49ers’ Bryce Huff, Jake Brendel To Miss Time

October 21st, 2025 at 9:48am CST by Adam La Rose

Week 7 saw the 49ers improve to 5-2 on the year. The team is now dealing with even more injuries, though, and San Francisco’s edge rush group has been dealt another blow.

Defensive end Bryce Huff has a hamstring injury, head coach Kyle Shanahan said (via ESPN’s Nick Wagoner). An absence of multiple weeks is expected as a result. Starting center Jake Brendel finds himself in the same situation as Huff.

Matt Hennessey filled in at center to close out Sunday’s contest, and he could continue in that role moving forward while Brendel recovers. The interior of San Francisco’s offensive line could manage in that instance, but the team’s depth along the edge is now even more of a concern. Nick Bosa is out for the remainder of the season due to an ACL tear, something which has led many to expect a 49ers pass rush trade acquisition in the near future.

With Bosa sidelined, Huff has taken on an increased role. The former UDFA recorded one sack against the Falcons on Sunday, bringing his season total to four. After last year’s trade to the Eagles did not go as planned, Huff has managed to find success upon reuniting with 49ers defensive coordinator (and former Jets head coach) Robert Saleh. Having him unavailable for any period will be detrimental as a result. Shanahan added (via Wagoner’s colleague Adam Schefter) he hopes Huff does not miss more than two weeks.

General manager John Lynch has publicly confirmed the 49ers’ interest in making a trade to help compensate for Bosa’s absence along the edge, with 2024 sack leader Trey Hendrickson a name to watch on that front. More recently, however, he has suggested San Francisco could avoid costly acquisitions with not only Bosa but also All-Pro linebacker Fred Warner sidelined. It will be interesting to see how the team operates with two weeks remaining before the trade deadline given Huff’s status.

Tarron Jackson was moved to injured reserve in July after suffering a neck injury during practice. That move ended his campaign before it started, so instead of serving in a depth role behind Bosa and Huff he is on the mend as well. With a thin depth chart still in place along the edge, the 49ers will look to at least remain one of the NFC’s top teams until Huff is back in the fold.

NFL Practice Squad Updates: 10/20/25

October 20th, 2025 at 6:14pm CST by Ben Levine

Today’s practice squad moves:

Baltimore Ravens

Indianapolis Colts

San Francisco 49ers

David Long Jr. brings some experience to Indy’s practice squad, as the veteran defensive back has seen time in 79 career games. This included a 13-game showing with the Colts in 2024, although all but nine of his 117 snaps came on special teams. If he finds his way to the active roster, he’ll likely be eyeing a similar role this time around.

49ers Host LBs Workout

October 19th, 2025 at 6:39pm CST by Ely Allen

Last week, the 49ers suffered the loss of their best defensive player for the remainder of the season when Fred Warner‘s ankle was fractured and dislocated. The team officially placed him on injured reserve yesterday while, at the same time, hosting five free agent linebackers for workouts. Per Howard Balzer of CardsWire, linebackers Ben Niemann, Jalen Reeves-Maybin, Chandler Wooten, and two others were in San Francisco for the tryout yesterday.

One of the worst parts about losing a player as talented and reliable as Warner is that, considering he’s missed one of a possible 122 regular season games in his career, there usually isn’t much incentive to stack talent at the position behind him. The 49ers typically run two off-ball linebackers in their base defense. The starters are Warner and Dee Winters, and before last week’s game, there had only been five defensive snaps all season in which both were not on the field.

It was Tatum Bethune that subbed in for Warner in the remainder of last week’s game. Bethune was a seventh-round draft pick out of Florida State last year who played almost exclusively on special teams as a rookie. Appearing in 11 games, he saw defensive snaps in just five. He only saw more than four snaps in one game — the 6-11 team’s regular season finale in which Bethune was given a chance to start. The Week 18 start was not a sign of things to come, though. When Bethune entered for Warner last week, he was seeing his first defensive snaps since the three he played in Week 1 of this year.

So, while the 49ers may be comfortable moving forward with Bethune as the starting middle linebacker based on his familiarity with the defense over the past year and a half, one can hardly blame them for trying out some potential help. Niemann is the most experienced of the crowd. Starting his seven-year career in Kansas City, Niemann has been a dependable rotation defender for the Chiefs, Cardinals, and Lions over his career. He’s played in 103 total games, starting 25, and aside from his rookie season and a down year in Denver in 2023, Niemann’s averaged just over 50 tackles per season.

Reeves-Maybin is the next most experienced linebacker. Though he spent many years (seven in Detroit, one in Houston) as a depth piece and special teamer, Reeves-Maybin has shown he can perform as an injury replacement with 14 spot starts for the Lions, including 11 in 2021. He and Niemann were actually on the same defense in Detroit last year. Wooten was a depth piece and special teamer for the Panthers the last few years, earning two starts last year. He had signed briefly to San Francisco’s practice squad last year, returning to Carolina after a week.

The other two linebackers attending the workout were undrafted rookies Stone Blanton and Kam Arnold. Blanton signed with San Francisco out of Mississippi State, spending the offseason with the 49ers before failing to make the initial 53-man roster. Arnold, coming out of Boston College, followed a similar path with the Commanders. No contracts came immediately from yesterday’s workouts, but it will certainly be something to keep an eye on, depending on how Bethune performs in place of Warner as the season goes on.

Minor NFL Transactions: 10/18/25

October 18th, 2025 at 7:57pm CST by Ely Allen

Here are today’s minor moves and practice squad elevations as we head to the seventh Sunday of the regular season:

Arizona Cardinals

Atlanta Falcons

Chicago Bears

Green Bay Packers

Jacksonville Jaguars

Las Vegas Raiders

Los Angeles Rams

Miami Dolphins

New England Patriots

New Orleans Saints

New York Giants

New York Jets

Philadelphia Eagles

San Francisco 49ers

Tennessee Titans

As injured reserve activations start to dominate the headlines, a couple teams are making minor additions off their injured lists. In Homer, the Bears are getting a veteran special teamer and some running back depth. Monk adds depth to Green Bay’s offensive line. And Weston will do the same for a linebacking corps in New York that has seen rookie fifth-round pick Francisco Mauigoa starting in place of an injured Quincy Williams.

Ford in Chicago, Sewell in New Orleans, and Jacobs in Tennessee are all being called up as standard gameday practice squad elevations for the third time this year. In order to appear in any more games after this weekend, their respective teams will need to sign them to the 53-man roster.

49ers Activate TE George Kittle From IR

October 18th, 2025 at 3:22pm CST by Ely Allen

As the 49ers say goodbye to one star, they’ll welcome another. Opening a spot on the 53-man roster by officially placing linebacker Fred Warner on injured reserve, San Francisco will fill it with the activation of tight end George Kittle from IR. Kittle is joined as an IR activation by defensive tackle Kevin Givens.

After suffering a full tear of his right hamstring in a Week 1 win over the Seahawks, Kittle sat out five games – the second-highest total of his career. The six-time Pro Bowler will return to an offense that will go without starting quarterback Brock Purdy for the third straight game. With Purdy dealing with a toe injury, Mac Jones will lead the 4-2 Niners against the 3-2 Falcons on Sunday.

The multi-game absences of Kittle and Purdy have been among several injury-related setbacks for San Francisco’s offense this year. The defense also hasn’t been spared. Star pass rusher Nick Bosa went down with a season-ending ACL tear in Week 3. The unit took a similarly brutal shot when Warner dislocated and fractured his ankle in a loss to the Buccaneers last week. The four-time Pro Bowler underwent surgery and will miss the rest of the regular season. A playoff return for Warner is an extreme long shot.

With Warner out of commission, Tatum Bethune will face a gargantuan task in replacing one of the game’s preeminent defenders. Bethune, a seventh-round pick in 2024, has only made one start in 17 career games. Out of 134 snaps this year, just 48 have come on defense. Bethune has otherwise worked on special teams.

While San Francisco’s defense has lost Warner, it’s getting some D-line depth back with Givens set to make his season debut. Givens hasn’t played in 2025 as a result of a pectoral injury. The seventh-year 49er totaled 3.5 sacks and six QB hits in eight games last season.

In addition to the IR transactions, San Francisco announced that defensive end Trevis Gipson has been signed from the practice squad to the 53-man roster. Joining him for the weekend as standard gameday practice squad elevations will be wide receiver Malik Turner and offensive lineman Nick Zakelj. To make room for Gipson on the active roster, the 49ers waived tight Brayden Willis.

Connor Byrne contributed to this post.

49ers To Activate George Kittle, Rule Out Brock Purdy

October 17th, 2025 at 5:01pm CST by Nikhil Mehta

The 49ers ruled out quarterback Brock Purdy for Week 7, per The Athletic’s Vic Tafur, meaning that Mac Jones will make his fifth start of the season.

Purdy was still limited in practice this week due to a re-aggravation of his toe injury. Jones, meanwhile, progressed to full participation despite dealing with knee and oblique injuries. He has led the 49ers to a 3-1 record in his four starts with a league-high 313 passing yards per game.

Head coach Kyle Shanahan also said (via ESPN’s Nick Wagoner) that tight end George Kittle would be activated from injured reserve for Sunday’s game, ending his four-game absence due to a Week 1 hamstring injury. Kittle is not expected to be on any kind of snap count, according to Tafur.

San Francisco created the space for Kittle’s activation on Friday by placing wide receiver Marquez Valdes-Scantling on injured reserve, per Wagoner. The eight-year veteran will now be on the shelf for at least four games with a calf injury and becomes the latest 49ers wideout to miss time. Ricky Pearsall has been out for the last two games with a knee issue that will sideline him for Sunday’s contest as well. Jacob Cowing is on IR, though Shanahan said (via Wagoner) that he is “getting close” to returning to practice. Jauan Jennings has missed two games and played through four others with a litany of injuries. That’s not even mentioning Brandon Aiyuk, who will not be back until November at the earliest.

Kittle’s return will obviously go a long way in relieving the pressure on the 49ers’ injured receiving corps. Backup tight end Jake Tonges has performed well in his absence, giving Shanahan the options of using more two-tight end formations until the rest of his offense gets healthier.

Shanahan also said that defensive tackle Kevin Givens will “most likely” be activated from IR as well, which would add depth to a defensive line that has also dealt with a number of injuries this year. The 49ers can easily create a roster spot for Givens by placing linebacker Fred Warner on injured reserve after an ankle injury that is expected to end his season.

49ers Less Likely To Pursue Trades?

October 17th, 2025 at 11:09am CST by Adam La Rose

Not long after Nick Bosa suffered a torn ACL, John Lynch confirmed the 49ers were in the market for a trade aimed at adding a pass rusher. Trey Hendrickson in particular has emerged as a name to watch in that regard.

However, Week 6 saw linebacker Fred Warner suffer a fractured and dislocated ankle. The All-Pro is expected to miss the remainder of the campaign as a result. With San Francisco’s defense now missing two major contributors the rest of the way, the team’s general manager appears to have changed his stance on the subject of pursuing a short-term addition on the trade market.

“It’s time to go play. And we’ve got plenty in this team to go compete and go win football games,” Lynch said during his latest appearance on KNBR radio (via Eric Branch of the San Francisco Chronicle). “And you do your due diligence — you put the work in. Are there variables that change from week to week? Absolutely, there are. And we’ll just leave it at that.”

Indeed, the 49ers’ calculus has no doubt shifted with Bosa and now Warner out of the picture. The team sits at 4-2, but sacrificing draft capital for a rental could be more difficult to justify given the state of the defense on the injury front. In any event, the play of San Francisco’s internal options will be key in replacing Bosa and Warner down the stretch.

Hendrickson is one of several edge rushers who have emerged as trade candidates ahead of the November 4 deadline. Fewer linebackers have been mentioned in the same capacity, though. As things stand, Tatum Bethune is in position to assume a starting role in Warner’s place. The 2024 seventh-rounder has been a regular on special teams early in his career, but he has logged just 99 snaps on defense in the regular season. How Bethune fares with an increased workload will surely influence Lynch’s aggressiveness on the trade front.

With over $21MM in cap space, the 49ers can certainly afford a short-term acquisition. Based on Lynch’s latest comments, however, the team may prefer to avoid any notable outside additions and instead proceed with its in-house replacement options.

49ers, Colts, Eagles, Cowboys Among Potential Suitors For Trey Hendrickson

October 16th, 2025 at 10:59pm CST by Nikhil Mehta

All-Pro edge rusher Trey Hendrickson has emerged as a popular name in trade talks following an offseason contract saga with the Bengals and their subsequent 2-4 start to the season.

The 49ers are among the teams interested in trading for Hendrickson, though Cincinnati is reportedly not interested in moving him. Other expected suitors include the Colts, Eagles, and Cowboys, per Sportskeeda’s Tony Pauline. Hendrickson is owed $9.8MM for the rest of the season if traded after Week 8 ($8.9MM if after Week 9, per OverTheCap), and the Bengals will likely want an acquiring team to pick up all of his remaining salary.

We noted when the Colts restructured Kenny Moore‘s contract earlier this month that general manager Chris Ballard could be clearing space for a big swing ahead of the trade deadline to take advantage of a surprising 5-1 start. Going after Hendrickson, one of the league’s premier edge rushers, would certainly fall into that category. Indianapolis does not necessarily need the pass rush help – their 16 sacks are tied for seventh-most in the NFL – but no individual player has more than 3.0 sacks. Instead, they have 11 defenders who have contributed to a sack this year; adding Hendrickson to that group would give them an elite individual sack-getter on top of a well-schemed pass rush.

Eagles general manager Howie Roseman has a reputation of being a big-name hunter on the trade market, but most of his higher-profile deals have come during the offseason. However, Philadelphia has a bottom-10 pass rush with only nine sacks as a team and no player with more than two. Nolan Smith and Ogbo Okoronkwo are already on injured reserve, and Za’Darius Smith just retired, so the Eagles defense could definitely use reinforcements on the edge. Roseman’s aggressive cap management has given the team enough room to absorb’s Hendrickson’s contract, though it would tighten their budget for the rest of the season.

The Cowboys pass rush has predictably struggled following the departures of Micah Parsons and DeMarcus Lawrence, leading to one of the worst defensive units in the NFL. Jerry Jones recently hinted that he could be active ahead of the trade deadline, and he acknowledge that every asset would be on the table, including the picks acquired from Green Bay in the Parsons trade. The Cowboys could certainly use a player of Hendrickson’s caliber, as they currently have the ninth-fewest sacks in the NFL (11).

We heard recently that the 49ers see Hendrickson as “an ideal fit for their defense.” The team lost star pass rusher Nick Bosa to a season-ending ACL tear in Week 3, and 49ers general manager John Lynch has made it known that he’s looking for help on the edge. That front office hasn’t been afraid to take in-season swings, and it wouldn’t be surprising if the team acquired a player of Hendrickson’s talent as they look to maximize their current core.

As mentioned, the Bengals have resisted any trade inquires for their star pass rusher. However, if the team doesn’t improve as the trade deadline inches closer, there’s a chance the team starts fielding offers.

Ben Levine contributed to this post.

Mac Jones Likely To Start Week 7; George Kittle Plans To Return

October 16th, 2025 at 9:51pm CST by Connor Byrne

It appears 49ers backup quarterback Mac Jones will make his third straight start in place of Brock Purdy in Week 7. While Jones has been dealing with knee and oblique issues, he was able to practice in full on Thursday. With Purdy limited because of a nagging toe injury, head coach Kyle Shanahan said that Jones will “most likely” start against the Falcons on Sunday (via Eric Branch of the San Francisco Chronicle).

After playing 31 of a possible 34 regular-season games from 2023-24, Purdy has already sat out four times this year. He started a season-opening win over the Seahawks and a Week 4 loss to the Jaguars. The offseason decision to sign Jones, a former Patriot and Jaguar, has helped the injury-plagued 49ers stay afloat during a 4-2 start.

While Jones struggled in a loss to the Buccaneers last Sunday, the 49ers have gone 3-1 with him at the helm. The 27-year-old has connected on 67.3% of passes for 1,252 yards, six touchdowns, and three interceptions.

Jones’ success has come without six-time Pro Bowl tight end George Kittle, who’s among the Niners’ many walking wounded, but that could change Sunday. Kittle suffered a right hamstring injury in Week 1 – a “full tear,” he revealed – leading the 49ers to place him on IR. After missing five consecutive games, Kittle returned to practice on Wednesday. He took part in his second limited session in a row Thursday and expressed confidence about his chances of facing the Falcons.

“I fully plan on playing on Sunday,” Kittle said, though he acknowledged that Shanahan will make the call (via Nick Wagoner of ESPN.com).

While Jones may count Kittle among his weapons for the first time on Sunday, he could go without wide receiver Ricky Pearsall again. After missing San Francisco’s past two games with a knee injury, the second-year man has not returned to practiced this week.

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