As the Bills head to South Florida for a noon matchup against a red-hot Tua Tagovailoa and the Dolphins, they have seen a tough challenge get tougher. Buffalo released an injury update on its website today reporting that the team expects to be without four starters: two in the secondary, in safety Micah Hyde and cornerback Dane Jackson, and two defensive tackles, Ed Oliver and Jordan Phillips. Jackson, Hyde, and Phillips all left Monday night’s game with injuries, while Oliver will miss his second straight contest.

Jackson left the game last week after a collision that forced his head backwards in a scary-looking neck injury. He was taken off the field in an ambulance, but, luckily, avoided any major injury. Unfortunately, Jackson hasn’t been able to practice at all this week but has been able to be around the team at the facilities.

Hyde also suffered a neck injury, albeit a far less severe-looking injury than Jackson’s, that held him out of practice this week. Phillips left the game Monday with a hamstring injury and also was unable to practice this week. Oliver has been dealing with an ankle injury that held him out last week, as well.

Missing three starters in the secondary (cornerback Tre’Davious White remains on injured reserve) makes the prospect of facing Tagovailoa a bit more cumbersome one week after he threw for 469 yards and six touchdowns against a banged up Ravens secondary. They’ll turn to rookies Christian Benford and Kaiir Elam to fill in at cornerback with help from veteran Bills cornerbacks Taron Johnson and Siran Neal. Damar Hamlin and Jaquan Johnson will be asked to step up in Hyde’s absence, as well.

With both Phillips and Oliver out on the defensive line, it’s a good bet that the Bills will mirror their gameday practice squad call-ups from last week in defensive tackles C.J. Brewer and Brandin Bryant.

Here are a few more Sunday injury statuses we learned about today, starting with a couple of big starters out in Sin City:

• The Raiders are set to face off against the Titans this weekend without two Pro Bowlers as wide receiver Hunter Renfrow and linebacker Denzel Perryman are officially out, according to Adam Hill of the Las Vegas Review-Journal. Hill also reports that, after missing two practices with an illness, running back Josh Jacobs is questionable to play this Sunday.
• Despite initial reports in the preseason that Colts star linebacker Shaquille Leonard would not miss any time, the 27-year-old is set to miss his third straight game after being ruled out against the Chiefs this week, according to Mike Chappell of Indianapolis Fox59. Head coach Frank Reich told the media, “Deep down it’s the player. Deep down the player has to know he can play winning football and help this team win. That’s where we’ve got to get to.”