49ers’ Trent Williams Out For Week 18; George Kittle Plans To Play
5:40PM: As the 49ers prepare to take on the Seahawks for the No. 1 seed in the NFC, they will officially be doing so without Williams. San Francisco listed him as one of their inactive players for tonight’s game.
10:59AM: It appears the 49ers will go without future Hall of Fame left tackle Trent Williams in their pivotal regular-season finale against the Seahawks on Saturday. Williams, who suffered a hamstring injury in a win over the Bears last Sunday, did not practice this week. That suggests he won’t take the field with the NFC West and the No. 1 seed in the conference on the line, Ian Rapoport of NFL Network says.
If Williams sits Saturday, it’ll prevent the 37-year-old from logging his first 17-game campaign. A career-long starter since entering the NFL as a first-round pick (No. 4) with Washington in 2010, Williams has earned his 12th Pro Bowl nod this season. He’s Pro Football Focus’ third-ranked tackle out of 86 qualifiers.
It’s obviously less than ideal for the 49ers to go without Williams, but they pulled off a thrilling 42-38 win in Week 17 despite his absence. Williams played one snap before exiting, leaving Austen Pleasants to take over for the rest of the game. The fourth-year man will make the first start of his career Saturday if Williams is unavailable. It’ll be a tall order against a Seattle defense that ranks second in scoring, fifth in yards and eighth in sacks.
In better news for the 49ers, seven-time Pro Bowl tight end George Kittle said he “absolutely” plans to play in Week 18 (via Nick Wagoner of ESPN). Kittle, a limited participant in practice this week, missed the Chicago game with an ankle issue, continuing an injury-riddled year for him.
After suffering a right hamstring tear in a Week 1 victory in Seattle, Kittle spent over a month on IR. The 32-year-old has appeared in just 10 of 16 games this season, but when healthy enough to play, he has continued to post superb production. Kittle has hauled in 52 of 62 targets for 599 yards and seven touchdowns. Adding in Kittle’s blocking prowess, he’s PFF’s No. 1-ranked tight end among 75 qualifiers.
The 49ers have overcome a slew of notable injuries this year en route to a 12-4 record. While the team remains banged up, there’s only one more hurdle to clear to ensure homefield advantage through the playoffs. If the 49ers complete the season sweep of the Seahawks at home, they won’t go on the road again. That includes the Super Bowl, where the 49ers will host the AFC champion at Levi’s Stadium if they survive the NFC onslaught in January.
49ers Notes: Kittle, Williams, Warner, WRs
Trent Williams missed almost all of the 49ers’ 42-38 win, going down with a hamstring injury sustained as he attempted to make a tackle on Brock Purdy‘s first-play pick-six. The future Hall of Fame left tackle is undergoing tests today, per NFL.com’s Ian Rapoport. While this injury does not appear set to move Williams to IR, Rapoport points to a Week 18 absence being likely. The 49ers, after all, somewhat surprisingly (given their Seattle matchup’s importance) drew a short-week assignment for their regular-season finale.
Although the 49ers’ most notable injuries have involved season-enders (or apparent season-enders in Fred Warner‘s case), this heightens the importance of the team earning the NFC’s bye slot. Williams and George Kittle having recovery weeks would certainly be beneficial to this unlikely Super Bowl contender’s quest.
Here is the latest out of San Francisco:
- After three DNPs last week, Kittle missed the 49ers’ shootout win over the Bears. Swelling in the All-Pro tight end’s injured ankle prevented him from conducting a planned pregame workout, according to NBC’s Melissa Stark, leading to the Week 17 shutdown. Kittle, who came off IR earlier this season following a hamstring injury, expects to play in the 49ers’ Week 18 matchup. Charting the likely Hall of Famer’s practice log will be key, but Kittle appears to be readying to be available when the team matches up with the Seahawks for home-field advantage in the NFC playoffs.
- Warner’s comeback remains a talking point. Despite suffering a dislocated ankle in Week 6, the All-Pro linebacker said during NBC’s pregame show he has “a chance” to come back during the playoffs. No divisional-round return is expected, with Rapoport adding Warner’s earliest return point would likely come if the 49ers advance to the NFC championship game. This aligns with recent reporting on the linebacker’s recovery. This is generally a four- to six-month injury; as recently as late November, Kyle Shanahan said he did not expect Warner back until the 2026 season. But Rapoport points to the eighth-year defender returning in a partial role as a viable scenario should the 49ers’ season extend into late January.
- The 49ers have used five of their eight regular-season injury activations. In decent shape here, the 12-4 team will receive two more activations once the playoffs begin. One of those figures to go to Jacob Cowing, who has missed the entire season. Shanahan said Cowing — a 2024 fourth-round pick — was close to practicing in Week 17; the ninth-year HC expects Cowing’s IR-return window to open this week, The Athletic’s Matt Barrows notes. That would make Cowing, who has lingered on IR since late August due to a nagging hamstring injury, eligible to be activated ahead of Week 18. Cowing caught four passes for 80 yards last season.
- One of the wideouts the 49ers have needed to rely on due to the injuries to Cowing, Ricky Pearsall and Jauan Jennings this season — one also featuring a Brandon Aiyuk no-show — Kendrick Bourne reached an incentive during the 49ers’ Week 16 win over the Colts. Returning to the 49ers in September following a Patriots release, Bourne triggered a $500K incentive by surpassing 500 receiving yards, Stark noted (h/t Awful Announcing). Bourne has 551 yards; he can earn another $250K bump by reaching 600.
49ers Activate TE George Kittle From IR
As the 49ers say goodbye to one star, they’ll welcome another. Opening a spot on the 53-man roster by officially placing linebacker Fred Warner on injured reserve, San Francisco will fill it with the activation of tight end George Kittle from IR. Kittle is joined as an IR activation by defensive tackle Kevin Givens.
After suffering a full tear of his right hamstring in a Week 1 win over the Seahawks, Kittle sat out five games – the second-highest total of his career. The six-time Pro Bowler will return to an offense that will go without starting quarterback Brock Purdy for the third straight game. With Purdy dealing with a toe injury, Mac Jones will lead the 4-2 Niners against the 3-2 Falcons on Sunday.
The multi-game absences of Kittle and Purdy have been among several injury-related setbacks for San Francisco’s offense this year. The defense also hasn’t been spared. Star pass rusher Nick Bosa went down with a season-ending ACL tear in Week 3. The unit took a similarly brutal shot when Warner dislocated and fractured his ankle in a loss to the Buccaneers last week. The four-time Pro Bowler underwent surgery and will miss the rest of the regular season. A playoff return for Warner is an extreme long shot.
With Warner out of commission, Tatum Bethune will face a gargantuan task in replacing one of the game’s preeminent defenders. Bethune, a seventh-round pick in 2024, has only made one start in 17 career games. Out of 134 snaps this year, just 48 have come on defense. Bethune has otherwise worked on special teams.
While San Francisco’s defense has lost Warner, it’s getting some D-line depth back with Givens set to make his season debut. Givens hasn’t played in 2025 as a result of a pectoral injury. The seventh-year 49er totaled 3.5 sacks and six QB hits in eight games last season.
In addition to the IR transactions, San Francisco announced that defensive end Trevis Gipson has been signed from the practice squad to the 53-man roster. Joining him for the weekend as standard gameday practice squad elevations will be wide receiver Malik Turner and offensive lineman Nick Zakelj. To make room for Gipson on the active roster, the 49ers waived tight Brayden Willis.
Connor Byrne contributed to this post.
49ers To Activate George Kittle, Rule Out Brock Purdy
The 49ers ruled out quarterback Brock Purdy for Week 7, per The Athletic’s Vic Tafur, meaning that Mac Jones will make his fifth start of the season.
Purdy was still limited in practice this week due to a re-aggravation of his toe injury. Jones, meanwhile, progressed to full participation despite dealing with knee and oblique injuries. He has led the 49ers to a 3-1 record in his four starts with a league-high 313 passing yards per game.
Head coach Kyle Shanahan also said (via ESPN’s Nick Wagoner) that tight end George Kittle would be activated from injured reserve for Sunday’s game, ending his four-game absence due to a Week 1 hamstring injury. Kittle is not expected to be on any kind of snap count, according to Tafur.
San Francisco created the space for Kittle’s activation on Friday by placing wide receiver Marquez Valdes-Scantling on injured reserve, per Wagoner. The eight-year veteran will now be on the shelf for at least four games with a calf injury and becomes the latest 49ers wideout to miss time. Ricky Pearsall has been out for the last two games with a knee issue that will sideline him for Sunday’s contest as well. Jacob Cowing is on IR, though Shanahan said (via Wagoner) that he is “getting close” to returning to practice. Jauan Jennings has missed two games and played through four others with a litany of injuries. That’s not even mentioning Brandon Aiyuk, who will not be back until November at the earliest.
Kittle’s return will obviously go a long way in relieving the pressure on the 49ers’ injured receiving corps. Backup tight end Jake Tonges has performed well in his absence, giving Shanahan the options of using more two-tight end formations until the rest of his offense gets healthier.
Shanahan also said that defensive tackle Kevin Givens will “most likely” be activated from IR as well, which would add depth to a defensive line that has also dealt with a number of injuries this year. The 49ers can easily create a roster spot for Givens by placing linebacker Fred Warner on injured reserve after an ankle injury that is expected to end his season.
Mac Jones Likely To Start Week 7; George Kittle Plans To Return
It appears 49ers backup quarterback Mac Jones will make his third straight start in place of Brock Purdy in Week 7. While Jones has been dealing with knee and oblique issues, he was able to practice in full on Thursday. With Purdy limited because of a nagging toe injury, head coach Kyle Shanahan said that Jones will “most likely” start against the Falcons on Sunday (via Eric Branch of the San Francisco Chronicle).
After playing 31 of a possible 34 regular-season games from 2023-24, Purdy has already sat out four times this year. He started a season-opening win over the Seahawks and a Week 4 loss to the Jaguars. The offseason decision to sign Jones, a former Patriot and Jaguar, has helped the injury-plagued 49ers stay afloat during a 4-2 start.
While Jones struggled in a loss to the Buccaneers last Sunday, the 49ers have gone 3-1 with him at the helm. The 27-year-old has connected on 67.3% of passes for 1,252 yards, six touchdowns, and three interceptions.
Jones’ success has come without six-time Pro Bowl tight end George Kittle, who’s among the Niners’ many walking wounded, but that could change Sunday. Kittle suffered a right hamstring injury in Week 1 – a “full tear,” he revealed – leading the 49ers to place him on IR. After missing five consecutive games, Kittle returned to practice on Wednesday. He took part in his second limited session in a row Thursday and expressed confidence about his chances of facing the Falcons.
“I fully plan on playing on Sunday,” Kittle said, though he acknowledged that Shanahan will make the call (via Nick Wagoner of ESPN.com).
While Jones may count Kittle among his weapons for the first time on Sunday, he could go without wide receiver Ricky Pearsall again. After missing San Francisco’s past two games with a knee injury, the second-year man has not returned to practiced this week.
49ers Open George Kittle’s Practice Window
Star tight end George Kittle has been on IR since Sept. 9, but he’s finally nearing a return. The 49ers opened Kittle’s practice window on Wednesday, according to Clayton Holloway of NFL Network. They’ll have 21 days to activate him.
Kittle, who suffered a hamstring injury in a Week 1 win over the Seahawks, will practice on a limited basis on Wednesday. Head coach Kyle Shanahan said that quarterbacks Brock Purdy and Mac Jones will join Kittle as limited participants (via Matt Barrows of The Athletic).
Purdy, out back-to-back games with a toe injury, is viewed as more limited than Jones. While Jones is battling knee and oblique issues, he could make his third straight start Sunday against the Falcons.
Kittle has already missed five games this season, which is the second-highest total of his nine-year career. The six-time Pro Bowler entered 2025 off four consecutive seasons of at least 14 games played. He continued to thrive during a 15-game slate in 2024, catching 78 passes for 1,106 yards and eight touchdowns.
The 49ers were likely expecting more of the same from Kittle this season. Instead, he has been among many high-profile injury casualties for the club. San Francisco’s offense has gotten one appearance from Kittle, two from Purdy, and none from receiver Brandon Aiyuk. On the other side of the ball, the team has seen heart-and-soul defenders Fred Warner and Nick Bosa go down with season-ending injuries in recent weeks. Despite that, the 49ers have gotten off to a 4-2 start.
Without Kittle, the 49ers have turned to the little-known Jake Tonges as their primary tight end. To Tonges’ credit, he has done well filling in for Kittle. He entered the season with no catches over four games (all with Chicago in 2022), but Tonges has racked up 25 receptions, 34 targets, 224 yards, and three scores in six contests this year. He’ll serve as a solid No. 2 option at tight end when Kittle is back in the lineup, perhaps as early as this week.
The 49ers could also get Aiyuk back soon, which will further bolster their offense down the stretch as they vie for a playoff berth. Facing a fellow NFC postseason contender this week in the 3-2 Falcons, the 49ers may again have to overcome a Purdy absence. After signing a five-year, $265MM contract extension in the offseason, Purdy has been sidelined for most of 2025. Jones has held his own as a fill-in, but thanks in part to his own injury troubles, he struggled in a loss to the Buccaneers in Week 6.
49ers’ George Kittle Has Chance At Week 7 Return; November Reemergence Targeted For Brandon Aiyuk
Once again battered by injuries, the 49ers have still managed to reach 4-2 despite a spree of setbacks for the second straight season. Pro Bowlers Brock Purdy, George Kittle and Nick Bosa have missed time, and the Fred Warner loss deals a blow the team has not previously encountered.
On the team amid the 2020 and 2024 injury waves, Warner has missed one career game. The All-Pro linebacker has crafted a Hall of Fame-caliber resume during the 49ers’ Kyle Shanahan-era surge, but he will undergo surgery Wednesday and joins Bosa in being out for the season. The 49ers are eyeing trades on defense, but their offense is starting to look healthier (even if Jauan Jennings is playing through a significant rib injury).
[RELATED: 49ers Expected To Inquire On Trey Hendrickson Trade]
While Purdy’s status remains murky, Kittle is nearing a return. Shanahan does expect (via 49ers reporter Briana Jeannel) the All-Pro tight end will be designated for return from IR ahead of the Falcons matchup. This would allow the 49ers a ramp-up period, but Shanahan added (via NBC Sports Bay Area’s Matt Maiocco) the hope is Kittle returns for Week 7.
Although the 49ers’ injury trouble is again mounting, they are not in bad shape yet in terms of IR activations. The team has either seen key players suffer season-ending injuries (Bosa, Warner) or remain on the active roster in week-to-week setups (Purdy, Jennings, Ricky Pearsall). The 49ers did place starting guard Ben Bartch on IR, and he is eligible for activation this week. It is uncertain if Bartch will join Kittle in being designated for return.
Kittle went down with a hamstring injury in Week 1. The likely Hall of Fame-bound pass catcher suited up for 15 games last season and did not miss any time due to injury in 2023. Playing in at least 14 games in 2021 and ’22, Kittle has not missed this much time in a season since being part of the 49ers’ spate of maladies in 2020. He missed eight games that season, suffering a sprained knee and fractured foot during San Francisco’s 6-10 season.
With Pearsall on the active roster, the 49ers are moving closer to full strength after seeing both their top two receivers go down early this season. San Francisco’s true No. 1 receiver, however, remains on the reserve/PUP list. Brandon Aiyuk‘s timetable has been pushed back a bit. Week 6 was floated months ago as a loose return window, but that has come and gone. Shanahan has now mentioned Week 10 as an updated window (via Maiocco) but stopped short of providing a firm timetable.
Out since October 20, 2024 with an ACL tear, Aiyuk has been in rehab mode after the tear was not deemed clean. Joining Kittle in suffering an injury shortly after an offseason extension, Aiyuk has been unable to build on the second-team All-Pro season he produced in 2023. John Lynch said in late September the sixth-year veteran was “not close” returning, but Shanahan’s update does provide a semi-positive sign a reemergence near the midseason point is still in play.
Like the IR-return process, the 49ers would have a 21-day period to observe Aiyuk in practice before activating him. Given the length of Aiyuk’s rehab process, it would surprise if he suited up the week he was designated for return. It should be expected, based on this timeline, Aiyuk would be in the PUP-return window soon. But the 49ers will continue to make do with a ravaged receiver depth chart for the time being. Though, Kittle’s return will help the passing attack considerably while Aiyuk hits the recovery homestretch.
Latest On 49ers’ Injuries
San Francisco is one of a few teams that have been bitten especially hard by the injury bug this season. Luckily, they’ve avoided the injury to their star running back that had everyone worried about to start the year, but in a crucial divisional matchup last night, the 49ers’ injury report ruled out five players, including the starting quarterback and three wide receivers. 
San Francisco was able to pull out a victory in last night’s game despite the team that’s taken so many hits thus far taking a few more in Los Angeles. The successful trip saw injuries sustained by defensive tackles Kalia Davis, Yetur Gross-Matos, and rookie Alfred Collins, as well as rookie cornerback Upton Stout, according to Nick Wagoner of ESPN. The only one who appears to have gotten off easy is Stout, who avoided a high ankle sprain, just suffered a regular ankle sprain, and is currently day-to-day.
Davis, on the other hand, will require surgery to repair a broken bone in his hand. Per Ian Rapoport of NFL Network, the procedure was scheduled to take place today. There’s some thought that Davis could potentially miss as few as two games. As a defensive lineman, Davis doesn’t have too much use for the gripping mechanic of that appendage in a game, and some expect him to return to play with a club cast on his hand.
Gross-Matos had just come off his only full practice of the week as he worked his way back from a knee injury. While the knee seemingly held up last night, Gross-Matos is now set to miss time with a hamstring strain, which could mean a multi-week absence. The rookie, Collins, suffered a sprained knee. With the Thursday Night Football matchup allowing for a bit more time to recover before their next game, Collins may stand a chance at not missing time, depending on the severity of the sprain.
Lastly, while we knew that star tight end George Kittle would be eligible to return from injured reserve in Week 6 after being placed on list after the season opener, we’ve finally received some insight on a more specific timeline. Per Vic Tafur of The Athletic, head coach Kyle Shanahan informed the media that Kittle likely will not be able to make it back until at least Week 7. At best, this will limit the veteran in-line pass catcher to a five-game absence.
49ers To Place George Kittle On IR
A Week 1 hamstring injury is expected to sideline tight end George Kittle for a few games, so the 49ers have opted to place him on injured reserve and open up a roster spot, according to ESPN’s Adam Schefter.
Kittle, 31 will be sidelined for a minimum of four games, making him eligible to return for San Francisco’s Week 6 visit to Tampa Bay. It’s another blow to a 49ers offense that started the season without wide receivers Brandon Aiyuk (knee, PUP), Demarcus Robinson (suspension), and Jacob Cowing (hamstring, IR with a return designation). Robinson will be eligible to return in Week 4, while Aiyuk and Cowing will be out until at least Week 5.
The 49ers then saw Kittle and Jauan Jennings exit their regular season opener with Brock Purdy playing through shoulder and toe injuries to finish the game. Initial tests on Jennings’ shoulder indicated that his injury is not serious, but Kyle Shanahan was noncommittal about Purdy’s Week 2 status.
Kittle’s absence will lead to more opportunities for backup tight ends Luke Farrell and Jake Tonges. Both saw more playing time after Kittle exited Sunday’s game with Tonges bringing in a tough contested catch for the game-winning touchdown. Practice squad tight end Brayden Willis will likely be promoted to the 53-man roster, per The Athletic’s Matt Barrows.
This is Kittle’s first IR placement since 2021. He missed five games due to minor injuries over the last three years, but finished each season healthy. The nine-year veteran is coming off his fourth consecutive Pro Bowl season, which included 1,106 receiving yards and eight touchdowns, both the second-best marks of his career. He also posted career highs with 11.8 yards per target and an 83.0% catch rate. In Week 1, he caught four passes for 25 yards and a touchdown before leaving the game.
49ers’ George Kittle To Miss Multiple Weeks
While the 49ers escaped Week 1 with a victory, it wasn’t all positive news for the organization. George Kittle exited yesterday’s win in the first half after suffering a hamstring injury, and it sounds like the veteran tight end will miss a handful of games. While speaking with reporters today, coach Kyle Shanahan said Kittle will miss some time as he recovers from the injury (per ESPN’s Nick Wagoner).
While Shanahan indicated that his star TE will miss multiple weeks, he wouldn’t commit to Kittle landing on injured reserve (via Cam Inman of Bay Area News Group). Ian Rapoport of NFL Network has a more definitive timeline for the Pro Bowler, as a source indicated that Kittle would miss between three and five weeks. That timeline would make the player a prime candidate for IR.
While injuries were a theme early in Kittle’s career, the tight end has remained relatively healthy recently. Since being limited to eight games in 2020, the veteran has missed eight total contests over the past four years. He’s also continued to produce as he passed his age-30 season; after finishing the 2023 campaign with 1,022 yards, Kittle compiled 1,106 yards during the 2024 season. He seemed to pick up where he left off to start 2025, as he found the end zone to cap off San Francisco’s first offensive possession.
With Kittle out of the lineup, the 49ers will turn to Jake Tonges and Luke Farrell. Tonges made the most noise yesterday, hauling in three receptions, including the eventual game-winning touchdown.
The injuries don’t stop there. Shanahan revealed that quarterback Brock Purdy is dealing with both a shoulder and toe injury, with the coach stating “we’ll see” when asked about the player’s status for Week 2 (per Wagoner). Shanahan said the toe issue is more serious than the shoulder issue, and the team will use the upcoming week to evaluate the quarterback’s progress. If Purdy isn’t able to go against the Saints, Mac Jones would draw the start.
Finally, receiver Jauan Jennings was sidelined yesterday thanks to a shoulder injury. Shanahan told reporters that the team is still awaiting imaging on the wideout, although initial tests indicated that the player should be okay (per Wagoner). With Brandon Aiyuk out to start the season and Deebo Samuel no longer on the squad, the 49ers were going to be especially reliant on Jennings to begin the 2025 season. The 28-year-old hauled in a pair of catches for 16 yards before exiting yesterday’s game.