Arizona Cardinals News & Rumors

Cardinals To Start QB Jacoby Brissett In Week 6

By Adam La Rose | at October 12, 2025 10:41 am

OCT. 12: Brissett will start on Sunday. Murray is inactive, the team announced.

OCT. 11: The door is open to Kyler Murray handling quarterback duties for the Cardinals this week. As things stand, however, it is unlikely that will be the case.

Jacoby Brissett is expected to get the nod on Sunday, as first reported by ESPN’s Adam Schefter and Jeremy Fowler. Brissett has made a pair of appearances this season, his debut campaign in Arizona. He has yet to make a start for his latest team, though.

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Barring an unforeseen development, that will change tomorrow. Murray is still a possibility in terms of suiting up, but he was limited in practice on Friday after missing the previous two days. The former No. 1 pick’s foot ailment is a version of a Lisfranc injury, Ian Rapoport of NFL Network reports. As a result, Murray’s absence may not be limited to one game. His status will certainly be one to watch closely.

As of yesterday, the Cardinals were uncertain of their Week 6 starter; that left the team to craft plans for both Murray and Brissett. The latter is now in position to take on QB1 responsibilities for at least one week, however. Brissett has 53 starts and 83 appearances to his name. That includes a four-year spell with the Colts; Arizona will play Indianapolis in Week 6.

That Indy tenure included starting duties for two seasons. Brissett has also seen a multi-game run atop the depth chart with the Browns in 2022 while filling in for the suspended Deshaun Watson and at the start of last year before the Patriots handed the reins over to Drake Maye. The 32-year-old has not managed to post a winning record during any of his QB1 runs, but he will be counted on to keep Arizona’s offense afloat for at least one contest.

The Cardinals opened the season with two straight one-score wins, but they have lost three straight contests on game-ending field goals. Murray will be counted on to continue playing a central role in the efforts to reach the postseason when healthy, but his recovery process will determine the point at which he is back to full strength. It would come as little surprise if the Cardinals proceeded with caution in terms of his return to action given Murray’s status as their franchise passer (something all-but confirmed past the current campaign through his contract structure).

The 4-1 Colts have started out N0. 3 in the league in terms of points allowed this season. However, new DC Lou Anarumo‘s unit sits just 19th against the pass and injuries in the secondary remain a concern. That group will look to improve beginning tomorrow against a shorthanded Cardinals offense.

Cardinals Preparing For Kyler Murray Or Jacoby Brissett To Start

By Nikhil Mehta | at October 10, 2025 3:53 pm

OCTOBER 10: Murray returned to practice on Friday, per Cardinals senior writer Darren Urban. He is officially listed as questionable for Sunday’s game.

OCTOBER 9: With starting quarterback Kyler Murray dealing with a foot injury, the Cardinals are preparing for him or backup Jacoby Brissett to start in Week 6 in Indianapolis, per ESPN’s Jeremy Fowler.

Murray went down in Arizona’s Week 5 matchup with the Titans, but returned to finish the game. He then missed practice on Wednesday and Thursday, throwing his status for Sunday’s matchup with the Colts into doubt. Even if he practices Friday, he will be a “close call,” per Fowler, indicating that the Cardinals may be making a game-time decision on their starting quarterback.

During a 2-3 start for the Cardinals, Murray has completed 68.3 percent of passes for 962 yards, six touchdowns, and three interceptions.

As the dual threat continues distancing himself from the torn ACL he suffered in 2022, Murray made it clear during the offseason that he planned to run more this year. The 28-year-old has done just that, having averaged just under six rushes per game while amassing 173 yards (6.0 YPC) and a score. He posted an eye-popping 7.3 yards per rush last year during his first 17-game slate, though he did that on fewer than five attempts per contest.

With Murray relying so much on his mobility (he’s a career 3,000-yard rusher with 32 TDs on the ground), a foot injury is less than ideal and could lead the Cardinals to start Brissett on Sunday. The well-traveled veteran, 32, made the Cardinals the sixth organization of his career when he signed a two-year pact with them in the offseason.

Since debuting in 2016, Brissett has made 53 starts, including five with the Patriots in 2024. He connected on 59% of passes for 826 yards, two TDs, and a pick last year.

If Brissett plays this week, he’ll be facing one of his former teams. A Colt from 2017-20, Brissett took over as their starter when Andrew Luck abruptly retired in August 2019. The Brissett-led Colts went 7-9 that season. Six years since Luck stepped away, the Colts still haven’t found a franchise QB, though offseason free agent addition Daniel Jones has surprisingly played like one during a 4-1 start in 2025.

While Jones and the Colts are coming off a 40-6 rout of the Raiders, the Cardinals have dropped three in a row by a combined five points. They’ll hope Brissett can help turn their fortunes around if Murray is unable to play.

Connor Byrne contributed to this post.